Comprehensive Atherosclerotic Plaque Evaluation using Integrated Intravascular Ultrasound and Polarization-Sensitive OCT

Project: Research


  • Yan Li (PI)


Cardiovascular disease is the leading cause of death in developed countries, and ruptured atherosclerotic plaques are the main cause of acute coronary events. Intravascular ultrasound (IVUS) and intravascular optical coherence tomography (IVOCT) are the current clinical standard for plaque diagnostics. While both IVOCT and IVUS can provide structural information of the arterial wall, they cannot be used to study the mechanical integrity and chemical composition of the plaque, which are quantifiable metrics for determining plaque vulnerability. More recently, intravascular polarization-sensitive optical coherence tomography (PS-OCT) has been proposed to provide additional information for analyzing plaque vulnerability, but its clinical utility is limited due to the increased system complexity and cost. Furthermore, while each of these imaging modalities can uniquely characterize a plaque, the information provided by each alone is often insufficient to diagnose vulnerable plaque. Although all these techniques can be performed separately, by doing so it will increase the procedure cost, risk, and time, as well as X-ray exposure, and additional image co-registration steps will be necessary. To address these issues, we proposed a multimodal imaging technique that integrates IVUS, IVOCT, and intravascular PS-OCT for comprehensive plaque imaging. With a single imaging procedure, the proposed multimodal system will allow for simultaneous visualization of the structural morphology, mechanical integrity, and chemical composition of the plaque with high resolution, enhanced imaging depth, and high sensitivity. We believe the proposed imaging approach would provide clinicians a powerful tool for imaging and diagnosing plaque vulnerability, bringing profound impact to the field of interventional cardiology.
Award amount$128,080.00
Award date01/01/2020
Program typePostdoctoral Fellowship
Award ID20POST35200050
Effective start/end date01/01/202005/31/2022