Sudden cardiac arrest (SCA) is common, lethal, and debilitating, and responsible for over 300,000 deaths in the United States each year. Prevention and improved resuscitation measures are key strategies to lessening morbidity and mortality from SCA. A better understanding of causative factors will allow targeting of specific biologic processes for prevention. More precise risk stratification is also important, to identify high-risk individuals who will benefit most from prevention measures. An individualized approach to resuscitation that takes into account an individual's heterogeneous and evolving pathophysiology will improve resuscitation outcomes. Because women and men have different risk factors for cardiac arrest, experience cardiac arrest at different rates, and have a different likelihood of surviving a cardiac arrest event, we will look for both similarities and sex-differences in our proposed work. Our Center, a collaborative endeavor across three institutions (University of Washington, University of Rochester, and Johns Hopkins University), will use a genomic and precision medicine approach in clinical subjects and large populations to achieve our Center's overarching vision: to reduce SCA morbidity and mortality and promote high-quality research in SCA prevention and resuscitation care in men and women. Our proposal consists of the following three projects:Population Project 1: Nona Sotoodehnia, MD, MPH, Genomics of Sudden Cardiac Arrest Risk among Men and Women. Uses genomics to examine sex-specific causative risk factors for SCA and to identify those with high arrhythmic risk.Clinical Project 2: Ilan Goldenberg, MD (University of Rochester); Sex-Specific Risk for QTc Prolongation and Arrhythmic Events in Congenital Long QT Syndrome and Drug-Induced LQTS. Focused on influence of sex hormones on susceptibility to arrhythmic predisposition in congenital and drug-induced long QT syndrome patients.Population Project 3: Tom Rea, MD, MPH; Precision Medicine Resuscitation: Novel Strategy for Real-Time Rhythm Assessment during CPR in Men and Women. Uses innovative technology to assesses rhythm vitality during CPR to investigate how sex and other biological mechanisms might confer a survival advantage from SCA and be harnessed to a more directed and patient-tailored treatment approach to resuscitation.
|Program type||Strategically Focused Research Network|
|Effective start/end date||07/01/2019 → 06/30/2023|