In this proposal, we seek to enhance the performance of our 3-D electrochemical impedance spectroscopy (EIS) sensing modality for atherosclerosis and demonstrate that lesions prone to rupture and embolization have significant correlation with 3-D EIS. In standard procedure, the routine measurement of Fraction Flow Reserve (FFR), defined as the ratio of pressure across the stenotic lesions (Pdownstream/Pupstream) during coronary catheterization, determines the indication for intervention. For FFR > 0.8, patients are treated with medical therapy; for FFR <0.8, patients are referred for coronary revascularization. However, the predictors for eccentric and metabolically active, oxLDL-laden lesions prone to rupture remain largely undefined. In this context, we aim to demonstrate the fundamental translation of electrochemical impedance spectroscopy (EIS) in the pre-clinical swine models and to test the hypothesis that 3-D EIS mapping for endoluminal oxLDL-laden macrophages advances detection of atherosclerotic lesions prone to embolization.
|Effective start/end date||04/01/2019 → 03/31/2022|