Sudden cardiac arrest is responsible for 1/5 US deaths. When resuscitation is attempted outside the hospital, 20 minutes. These observations illustrate the time-sensitive nature of cardiac arrest interventions. We hypothesize that neuroprotective therapies are most effective when delivered within minutes of cardiac arrest onset. Our Center aims to improve neurologic outcomes of sudden cardiac arrest victims by developing, translating, and implementing treatments that can be reliably delivered within minutes of cardiac arrest onset by bystanders and first responders. This will require: 1) discovery and translation of new neuroprotective therapies with novel delivery mechanisms, 2) creation of innovative clinical trial methodologies, and 3) leveraging the learning health system model to optimize implementation of time-sensitive therapies during out-of-hospital cardiac arrest. Thus, our Center will undertake three synergistic projects: The Basic Project led by Thomas Sanderson, PhD, is entitled: Early Neuroprotective Therapies for Out-of-Hospital Cardiac Arrest. The Clinical Project led by Robert Silbergleit, MD, is entitled: Bystander and First Responders Clinical Trials for Early Neuroprotective Therapies in Out-of-Hospital Cardiac Arrest. The Population Project led by Brahmajee Nallamothu, MD, MPH, is entitled: Optimizing Bystander and First Responder Time to Treatment in Out-of-Hospital Cardiac Arrest. Our Training Program led by David Pinsky, MD, will attract candidates with diverse backgrounds and prepare them to become leaders in basic, clinical, or population research on treatment of sudden cardiac arrest. Overall, our expertise and experience, track record of collaboration, and resources at the University of Michigan make us uniquely qualified to execute our integrated Center aims and train the next generation of leaders in resuscitation science. We fully anticipate the results will directly improve cardiac arrest outcomes and transform the field by focusing research efforts on interventions that can be delivered within the most effective therapeutic window for neuroprotection after cardiac arrest.
|Program type||Strategically Focused Research Network|
|Effective start/end date||07/01/2019 → 06/30/2023|