Non-coding RNAs in ischemic myocardial disease and diabetes: discovery, pathobiology, and therapeutic intervention

Project: SFRN

Investigators

  • Mark W Feinberg (PI)

Description

Subjects with diabetes suffer a proportionately higher burden of ischemic cardiovascular disease (CVD) and develop an accelerated progression of cardiovascular complications. Therefore, innovative biomarkers and therapies are desperately needed in subjects with diabetes to reduce the development (atherosclerosis) and outcomes of ischemic CVD (myocardial injury and heart failure). Current paradigms suggest that endothelial cell (EC) inflammation and pre-mature senescence are critically involved. However, the mechanisms controlling these processes are not fully understood. While modern drug discovery has focused on protein targets, protein-coding genes represent
Award amount$954,732.00
Award date01/01/2020
Program typeStrategically Focused Research Network
Award ID20SFRN35200163
Effective start/end date01/01/202012/31/2023
StatusActive