Peripheral artery disease (PAD) is a highly prevalent condition in the United States, and a significant cause of cardiovascular morbidity and all-cause mortality. Although vascular surgical procedures are commonly performed to improve patient survival and quality of life and to prevent vascular disease related complications, these procedures carry heightened risk of adverse perioperative cardiovascular events. Pathological and clinical studies consistently demonstrate that platelets are a major culprit in the pathogenesis of atherothrombosis. There is increasing evidence that measurement of platelet activity can identify individuals at increased cardiovascular risk, yet most studies are small, lack comparative data on platelet measurements, and do not include patients with PAD. Data from the PI and others demonstrate novel, reliable, and reproducible measurements of increased platelet activity, thus allowing investigation of this clinically relevant and potentially modifiable cardiovascular risk factor in this very high-risk population.The proposed study will examine a panel of platelet activity markers and assess their ability to predict cardiovascular events following vascular surgery. The long-term goal is to develop a clinically useful assessment of platelet activity for risk stratification that may ultimately serve as a target for therapeutic intervention. The platform proposed will serve as a basis for future research and intervention, and hopefully, will have a great impact on subjects undergoing vascular surgery.
|Program type||Mentored Clinical & Population Research Program|
|Effective start/end date||01/01/2013 → 06/30/2015|