Selective serotonin reuptake inhibitors to enhance neuroplasticity in chronic stroke

Project: Research


  • Stuart Willaim Mackenzie (PI)


Selective serotonin reuptake inhibitors have demonstrated potential to enhance motor recovery after stroke, but the mechanisms underlying their effects have not been fully elucidated. The overall goal of the proposed research is to determine the effects of selective serotonin reuptake inhibitors (SSRIs) on paired associative stimulation-induced facilitatory and inhibitory neuroplasticity in the post-stroke brain using non-invasive transcranial magnetic stimulation (TMS). The knowledge gained in this research will establish a mechanistic basis for the development of SSRIs for stroke recovery, with a well-defined dose and mechanism of action, in patients with chronic stroke. Adjunctive treatment with SSRIs to enhance plasticity is promising approach to reducing the burden of stroke for chronic stroke survivors.
Award amount$131,356.00
Award date01/01/2020
Program typePostdoctoral Fellowship
Award ID20POST35210741
Effective start/end date01/01/202012/31/2021