In healthy adults, blood pressure (BP) is characterized by a circadian pattern over a 24-hour period with levels that are normally highest while awake and fall ('dip') during sleep. Individuals who do not have a fall in BP during sleep have reduced BP dipping. Reduced BP dipping is associated with increased target organ damage, cardiovascular events, and mortality, however the mechanisms underlying reduced BP dipping are unknown. The proposed research study examines the association between poor sleep architecture and reduced BP Dipping. A second objective is to determine whether autonomic function partially explains the association between poor sleep architecture and reduced BP dipping.The proposed AMFDP award will provide mentored career development and research activities that will enable Dr. Marwah Abdalla to build an independent program of patient-oriented research focusing on the mechanistic link between hypertension and sleep disorders.
|Program type||AHA AMFDP Scholar|
|Effective start/end date||07/01/2018 → 06/30/2022|