In cardiogenic pulmonary edema, liquid enters the alveolar air-space of the lung. Liquid- and air-filled alveoli, which are interspersed, exhibit different mechanics. As a result, ventilation of the edematous lung is thought to over-distend alveoli remaining air-filled. Our methods enable generation of an alveolar edema model and determination of alveolar compliance by confocal microscopy in the isolated, perfused rat lung. With these methods, we propose to characterize fully the mechanics of the edematous alveolus. We will develop a new technique for determining surface tension; use surface tension results to determine alveolar liquid phase pressure; and determine directly the location of inflation-induced injury. Finally, we will design a ventilation pattern that will manipulate the mechanics of the edematous alveolus in order to alleviate ventilator induced lung injury.
|Program type||Scientist Development Grant|
|Effective start/end date||07/01/2009 → 06/30/2012|