Cleveland Clinic Foundation

City Cleveland
State Ohio
  1. 2020
  2. Published

    Multicenter Analysis of Dosing Protocols for Sotalol Initiation

    Minakshi Biswas, Andrew Levy, Rachel Weber, Khaldoun Tarakji, Mina Chung, Peter A. Noseworthy & 2 others, Christopher Newton-Cheh & Michael A. Rosenberg, May 1 2020, In : Journal of Cardiovascular Pharmacology and Therapeutics. 25, 3, p. 212-218 7 p.

    Research output: Contribution to journalArticle

  3. Published

    Predictors of Improved Aerobic Capacity in Individuals With Chronic Stroke Participating in Cycling Interventions

    Susan M. Linder, Sara Davidson, Anson Rosenfeldt, Amanda Penko, John Lee, Mandy Miller Koop & 2 others, Dermot Phelan & Jay L. Alberts, Apr 2020, In : Archives of physical medicine and rehabilitation. 101, 4, p. 717-721 5 p.

    Research output: Contribution to journalArticle

  4. Published

    Pro-elastogenic effects of mesenchymal stem cell derived smooth muscle cells in a 3D collagenous milieu

    Shataakshi Dahal, Ganesh Swaminathan, Sarah Carney, Tom Broekelmann, Robert Mecham & Anand Ramamurthi, Mar 15 2020, In : Acta Biomaterialia. 105, p. 180-190 11 p.

    Research output: Contribution to journalArticle

  5. Published

    Identification of a hormone response element that mediates suppression of APOF by LXR and PPARα agonists

    Yan Liu, Lahoucine Izem & Richard E. Morton, Mar 2020, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1865, 3, 158583.

    Research output: Contribution to journalArticle

  6. Published

    Efficient Site-Specific Prokaryotic and Eukaryotic Incorporation of Halotyrosine Amino Acids into Proteins

    Hyo Sang Jang, Xiaodong Gu, Richard B. Cooley, Joseph J. Porter, Rachel L. Henson, Taylor Willi & 3 others, Joseph A. Didonato, Stanley L. Hazen & Ryan A. Mehl, Feb 21 2020, In : ACS chemical biology. 15, 2, p. 562-574 13 p.

    Research output: Contribution to journalArticle

  7. Published

    Research Needs and Priorities for Catheter Ablation of Atrial Fibrillation: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop

    Sana M. Al-Khatib, Emelia J. Benjamin, Alfred E. Buxton, Hugh Calkins, Mina K. Chung, Anne B. Curtis & 24 others, Patrice Desvigne-Nickens, Pierre Jais, Douglas L. Packer, Jonathan P. Piccini, Yves Rosenberg, Andrea M. Russo, Paul J. Wang, Lawton S. Cooper, Alan S. Go, Sana M. Al-Khatib, Emelia J. Benjamin, Alfred E. Buxton, Hugh Calkins, Mina K. Chung, Anne B. Curtis, Patrice Desvigne-Nickens, Pierre Jais, Douglas L. Packer, Jonathan P. Piccini, Yves Rosenberg, Andrea M. Russo, Paul J. Wang, Lawton S. Cooper & Alan S. Go, Feb 11 2020, In : Circulation. p. 482-492 11 p.

    Research output: Contribution to journalArticle

  8. Published

    Case Fatality Decline from 2009 to 2013 among Medicare Beneficiaries with Ischemic Stroke

    Shumei Man, Jesse D. Schold & Ken Uchino, Feb 2020, In : Journal of Stroke and Cerebrovascular Diseases. 29, 2, 104559.

    Research output: Contribution to journalArticle

  9. Published

    Editorial commentary: A CRISPR approach to the study and treatment of cardiovascular disease

    Shamone R. Gore-Panter & David R. Van Wagoner, Feb 2020, In : Trends in cardiovascular medicine. 30, 2, p. 102-103 2 p.

    Research output: Contribution to journalEditorial

  10. Published

    ADAMTS Proteins: Concepts, Challenges, and Prospects

    Suneel S. Apte, Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 1-12 12 p. (Methods in Molecular Biology; vol. 2043).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  11. Published

    Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage

    Lahoucine Izem, Yan Liu & Richard E. Morton, Jan 1 2020, In : Journal of lipid research. 61, 3, p. 422-431 10 p.

    Research output: Contribution to journalArticle

  12. Published

    Expression Analysis by RNAscope™ In Situ Hybridization

    Timothy J. Mead & Suneel S. Apte, Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 173-178 6 p. (Methods in Molecular Biology; vol. 2043).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  13. Published

    Visualization and Quantification of Pericellular Matrix

    Timothy J. Mead & Suneel S. Apte, Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 261-264 4 p. (Methods in Molecular Biology; vol. 2043).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  14. Published

    Randomized controlled trial of SystemCHANGE™ weight management intervention in neurological conditions

    Matthew Plow, Shirley M. Moore, Julia Chang, Emrose Bachhal & Kenneth E. Sparks, Jan 2020, In : Patient Education and Counseling. 103, 1, p. 112-119 8 p.

    Research output: Contribution to journalArticle

  15. 2019
  16. Published

    Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy

    Sherice Williams, Mohammed Hossain, Lisa Ferguson, Robyn M. Busch, Nicola Marchi, Jorge Gonzalez-Martinez & 3 others, Emilio Perucca, Imad M. Najm & Chaitali Ghosh, Dec 1 2019, In : Molecular Neurobiology. 56, 12, p. 8392-8407 16 p.

    Research output: Contribution to journalArticle

  17. Published

    Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation

    Lisa M. Grove, Maradumane L. Mohan, Susamma Abraham, Rachel G. Scheraga, Brian D. Southern, James F. Crish & 2 others, Sathyamangla V. Naga Prasad & Mitchell A. Olman, Nov 12 2019, In : Science signaling. 12, 607, eaau1533.

    Research output: Contribution to journalArticle

  18. Published

    Alterations in phenotype and gene expression of adult human aneurysmal smooth muscle cells by exogenous nitric oxide

    Kurt Farrell, Phillip Simmers, Gautam Mahajan, Ludovic Boytard, Andrew Camardo, Jyotsna Joshi & 3 others, Anand Ramamurthi, Florence Pinet & Chandrasekhar R. Kothapalli, Nov 1 2019, In : Experimental cell research. 384, 1, 111589.

    Research output: Contribution to journalArticle

  19. Published

    HDL flux is higher in patients with nonalcoholic fatty liver disease

    Arthur McCullough, Stephen F. Previs, Jaividhya Dasarathy, Kwangwon Lee, Abdullah Osme, Chunki Kim & 5 others, Serguei Ilchenko, Shuhui W. Lorkowski, Jonathan D. Smith, Srinivasan Dasarathy & Takhar Kasumov, Nov 1 2019, In : American journal of physiology. Endocrinology and metabolism. 317, 5, p. E852-E862

    Research output: Contribution to journalArticle

  20. Published

    Insights from Atrial Fibrillation Genomics: From Bedside to Bench and Back Again

    Mina K. Chung, So Jin Youn Wass & John Barnard, Nov 1 2019, In : Cardiology in Review. 27, 6, p. 302-307 6 p.

    Research output: Contribution to journalReview article

  21. Published

    Interferon-responsive genes are targeted during the establishment of human cytomegalovirus latency

    Elizabeth G. Elder, Benjamin A. Krishna, James Williamson, Eleanor Y. Lim, Emma Poole, George X. Sedikides & 4 others, Mark Wills, Christine M. O’connor, Paul J. Lehner & John Sinclair, Nov 1 2019, In : mBio. 10, 6, e02574-19.

    Research output: Contribution to journalArticle

  22. Published

    Obesity-linked suppression of membrane-bound o-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.

    Robert N. Helsley, Venkateshwari Varadharajan, Amanda L. Brown, Anthony D. Gromovsky, Rebecca C. Schugar, Iyappan Ramachandiran & 27 others, Kevin Fung, Mohammad Nasser Kabbany, Rakhee Banerjee, Chase Neumann, Chelsea Finney, Preeti Pathak, Danny Orabi, Lucas J. Osborn, William Massey, Renliang Zhang, Anagha Kadam, Brian E. Sansbury, Calvin Pan, Jessica Sacks, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Madeleine E. Lemieux, Valentin Gogonea, John P. Kirwan, Daniela S. Allende, Mete Civelek, Paul L. Fox, Lawrence L. Rudel, Aldons J. Lusis, Matthew Spite & J. Mark Brown, Oct 2019, In : eLife. 8, p. 1-69 69 p.

    Research output: Contribution to journalArticle

  23. Published

    Bilateral Contralaterally Controlled Functional Electrical Stimulation Reveals New Insights Into the Interhemispheric Competition Model in Chronic Stroke

    David A. Cunningham, Jayme S. Knutson, Vishwanath Sankarasubramanian, Kelsey A. Potter-Baker, Andre G. Machado & Ela B. Plow, Sep 1 2019, In : Neurorehabilitation and Neural Repair. 33, 9, p. 707-717 11 p.

    Research output: Contribution to journalArticle

  24. Published

    Interdependence of hypoxia and β-adrenergic receptor signaling in pulmonary arterial hypertension

    Olivia R. Stephens, Kelly Weiss, Matthew Frimel, Jonathan A. Rose, Yu Sun, Kewal Asosingh & 4 others, Samar Farha, Kristin B. Highland, Sathyamangla V.Naga Prasad & Serpil C. Erzurum, Sep 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 3, p. L369-L380

    Research output: Contribution to journalArticle

  25. Published

    Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1

    Juan Gao, Yun Bao, Shushu Ge, Peisen Sun, Jiaojiao Sun, Jianmin Liu & 7 others, Feng Chen, Li Han, Zhongyuan Cao, Jun Qin, Gilbert C. White, Zhen Xu & Yan Qing Ma, Aug 20 2019, In : Cell Communication and Signaling. 17, 1, 101.

    Research output: Contribution to journalArticle

  26. Published

    Forced, Not Voluntary, Aerobic Exercise Enhances Motor Recovery in Persons With Chronic Stroke

    Susan M. Linder, Anson B. Rosenfeldt, Sara Davidson, Nicole Zimmerman, Amanda Penko, John Lee & 2 others, Cynthia Clark & Jay L. Alberts, Aug 1 2019, In : Neurorehabilitation and Neural Repair. 33, 8, p. 681-690 10 p.

    Research output: Contribution to journalArticle

  27. Published

    Miltefosine increases macrophage cholesterol release and inhibits NLRP3-inflammasome assembly and IL-1β release

    Amanda J. Iacano, Harvey Lewis, Jennie E. Hazen, Heather Andro, Jonathan D. Smith & Kailash Gulshan, Jul 31 2019, In : Scientific reports. 9, 1, 1 p., 11128.

    Research output: Contribution to journalArticle

  28. Published

    Confirmation of Ath26 locus on chromosome 17 and identification of Cyp4f13 as an atherosclerosis modifying gene

    Juying Han, Peggy Robinet, Brian Ritchey, Heather Andro & Jonathan D. Smith, Jul 2019, In : Atherosclerosis. 286, p. 71-78 8 p.

    Research output: Contribution to journalArticle

  29. Published

    A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9) regulates fibronectin fibrillogenesis and turnover

    Lauren W. Wang, Sumeda Nandadasa, Douglas S. Annis, X. Joanne Dubail, Deane F. Mosher, Belinda B. Willard & 1 others, Suneel S. Apte, Jun 21 2019, In : Journal of Biological Chemistry. 294, 25, p. 9924-9936 13 p.

    Research output: Contribution to journalArticle

  30. Published

    Genetic Deficiency of Flavin-Containing Monooxygenase 3 (Fmo3) Protects Against Thrombosis but Has only a Minor Effect on Plasma Lipid Levels-Brief Report

    Diana M. Shih, Weifei Zhu, Rebecca C. Schugar, Yonghong Meng, Xun Jia, Aika Miikeda & 10 others, Zeneng Wang, Marina Zieger, Richard Lee, Mark Graham, Hooman Allayee, Rita M. Cantor, Christian Mueller, J. Mark Brown, Stanley L. Hazen & Aldons J. Lusis, Jun 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 6, p. 1045-1054 10 p.

    Research output: Contribution to journalArticle

  31. Published

    Progression of coronary microvascular dysfunction to heart failure with preserved ejection fraction: A case report

    Sandy Joung, Janet Wei, Michael D. Nelson, Haider Aldiwani, Chrisandra Shufelt, Balaji Tamarappoo & 3 others, Daniel Berman, Louise E.J. Thomson & C. Noel Bairey Merz, May 6 2019, In : Journal of Medical Case Reports. 13, 1, 134.

    Research output: Contribution to journalArticle

  32. Published

    Differential effect of short-term popular diets on TMAO and other cardio-metabolic risk markers

    J. E. Park, M. Miller, J. Rhyne, Z. Wang & S. L. Hazen, May 2019, In : Nutrition, Metabolism and Cardiovascular Diseases. 29, 5, p. 513-517 5 p.

    Research output: Contribution to journalArticle

  33. Published

    Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis

    Taesik Gwag, Zhaojie Meng, Yipeng Sui, Robert N. Helsley, Se Hyung Park, Shuxia Wang & 2 others, Richard N. Greenberg & Changcheng Zhou, May 2019, In : Journal of Hepatology. 70, 5, p. 930-940 11 p.

    Research output: Contribution to journalArticle

  34. Published

    Interleukin-27 promotes CD8+ T cell reconstitution following antibody-mediated lymphoablation

    Katayoun Ayasoufi, Daniel B. Zwick, Ran Fan, Suheyla Hasgur, Michael Nicosia, Victoria Gorbacheva & 4 others, Karen S. Keslar, Booki Min, Robert L. Fairchild & Anna Valujskikh, Apr 4 2019, In : JCI Insight. 4, 7, e125489.

    Research output: Contribution to journalArticle

  35. Published

    Risk factor modification: Another win for our fight against atrial fibrillation

    Lin Y. Chen & Mina K. Chung, Apr 1 2019, In : Europace. 21, 4, p. 527-528 2 p.

    Research output: Contribution to journalEditorial

  36. Published

    Atrial Tachyarrhythmias Among Patients With Left Ventricular Assist Devices: Prevalence, Clinical Outcomes, and Impact of Rhythm Control Strategies

    Andrew E. Noll, Joseph Adewumi, Ram Amuthan, Carl B. Gillombardo, Zariyat Mannan, Erich L. Kiehl & 6 others, Ayman A. Hussein, Mina K. Chung, Oussama M. Wazni, Randall C. Starling, Edward G. Soltesz & Daniel J. Cantillon, Apr 2019, In : JACC: Clinical Electrophysiology. 5, 4, p. 459-466 8 p.

    Research output: Contribution to journalArticle

  37. Published

    Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes

    Hyosuk Cho, Gong Qing Shen, Xiaofeng Wang, Fan Wang, Stephen Archacki, Yabo Li & 4 others, Gang Yu, Susmita Chakrabarti, Qiuyun Chen & Qing Kenneth Wang, Mar 15 2019, In : Journal of Biological Chemistry. 294, 11, p. 3881-3898 18 p.

    Research output: Contribution to journalArticle

  38. Published

    New Model of Automated Patient-Reported Outcomes Applied in Atrial Fibrillation

    Ayman A. Hussein, Bruce Lindsay, Ruth Madden, David Martin, Walid I. Saliba, Khaldoun G. Tarakji & 14 others, Bilal Saqi, David J. Rausch, Thomas Dresing, Thomas Callahan, Mina K. Chung, Bryan Baranowski, Mandeep Bhargava, Daniel Cantillon, John Rickard, Mohamed Kanj, Patrick Tchou, Bruce L. Wilkoff, Steven E. Nissen & Oussama M. Wazni, Mar 1 2019, In : Circulation: Arrhythmia and Electrophysiology. 12, 3, e006986.

    Research output: Contribution to journalArticle

  39. Published

    Life-Threatening Complications of Atrial Fibrillation Ablation: 16-Year Experience in a Large Prospective Tertiary Care Cohort

    Karim Abdur Rehman, Oussama M. Wazni, Amr F. Barakat, Walid I. Saliba, Shailee Shah, Khaldoun G. Tarakji & 13 others, John Rickard, Mohamed Bassiouny, Bryan Baranowski, Patrick J. Tchou, Mandeep Bhargava, Thomas J. Dresing, Thomas D. Callahan, Daniel J. Cantillon, Mina Chung, Mohamed Kanj, Samuel Irefin, Bruce Lindsay & Ayman A. Hussein, Mar 2019, In : JACC: Clinical Electrophysiology. 5, 3, p. 284-291 8 p.

    Research output: Contribution to journalArticle

  40. Published

    Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women

    Zeneng Wang, Nathalie Bergeron, Bruce S. Levison, Xinmin S. Li, Sally Chiu, Jia Xun & 6 others, Robert A. Koeth, Li Lin, Yuping Wu, W. H.Wilson Tang, Ronald M. Krauss & Stanley L. Hazen, Feb 14 2019, In : European heart journal. 40, 7, p. 583-594 12 p.

    Research output: Contribution to journalArticle

  41. Published

    Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection

    Abul Arif, Jie Jia, Belinda Willard, Xiaoxia Li & Paul L. Fox, Feb 7 2019, In : Molecular cell. 73, 3, p. 446-457.e6

    Research output: Contribution to journalArticle

  42. Published

    Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos

    Benjamin A. Krishna, Monica S. Humby, William E. Miller & Christine M. O’Connor, Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1755-1764 10 p.

    Research output: Contribution to journalArticle

  43. Published

    Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts

    Janet K. Lighthouse, Ryan M. Burke, Lissette S. Velasquez, Ronald A. Dirkx, Alessandro Aiezza, Christine S. Moravec & 3 others, Jeffrey D. Alexis, Alex Rosenberg & Eric M. Small, Jan 10 2019, In : JCI Insight. 4, 1, e92098.

    Research output: Contribution to journalArticle

  44. Published

    Antibody and synthetic peptide-based smart targeting of matrix regenerative nanoparticles for aortal wall repair

    Andrew Camardo & Anand Ramamurthi, Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, Vol. 40. 1 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  45. Published

    ApoF knockdown increases cholesteryl ester transfer to LDL and impairs cholesterol clearance in fat-fed hamsters

    Richard E. Morton, Yan Liu & Lahoucine Izem, Jan 1 2019, In : Journal of lipid research. 60, 11, p. 1868-1879 12 p.

    Research output: Contribution to journalArticle

  46. Published

    Imaging and atrial fibrillation: A new paradigm for precision targeting of AF?

    Mina K. Chung, Sojin Y. Wass & Manuel Cerqueira, Jan 1 2019, In : Journal of Nuclear Cardiology.

    Research output: Contribution to journalEditorial

  47. Published

    Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis

    Sarah R. Anthony, Adrienne R. Guarnieri, Anamarie Gozdiff, Robert N. Helsley, Albert Phillip Owens & Michael Tranter, Jan 1 2019, In : Clinical Science. 133, 22, p. 2329-2344 16 p.

    Research output: Contribution to journalReview article

  48. Published

    Stem cells-derived nano-vesicles for augmented regenerative repair of vascular elastic matrix

    S. Sajeesh & Anand Ramamurthi, Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  49. Published

    Targeting adult stem cell-derived smooth muscle cells to the aortal wall for augmented ecm repair

    Shataakshi Dahal & Anand Ramamurthi, Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  50. 2018
  51. Published

    Nonlinearly Generated Second Harmonic Ultrasonic Backscatter for Determining Composition of Human Carotid Plaque

    Russell James Fedewa, Sheronica James, Heather Gornik, Sean Lyden & D. Geoffrey Vince, Dec 17 2018, 2018 IEEE International Ultrasonics Symposium, IUS 2018. IEEE Computer Society, 8579649. (IEEE International Ultrasonics Symposium, IUS; vol. 2018-October).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  52. Published

    Mechanical dyssynchrony with phase analysis of gated SPECT: Nap time is over

    Wael AlJaroudi, Dec 15 2018, In : Journal of Nuclear Cardiology. 25, 6, p. 2039-2043 5 p.

    Research output: Contribution to journalEditorial

  53. Published

    Association between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation

    Seung Hoan Choi, Lu Chen Weng, Carolina Roselli, Honghuang Lin, Christopher M. Haggerty, M. Benjamin Shoemaker & 44 others, John Barnard, Dan E. Arking, Daniel I. Chasman, Christine M. Albert, Mark Chaffin, Nathan R. Tucker, Jonathan D. Smith, Namrata Gupta, Stacey Gabriel, Lauren Margolin, Marisa A. Shea, Christian M. Shaffer, Zachary T. Yoneda, Eric Boerwinkle, Nicholas L. Smith, Edwin K. Silverman, Susan Redline, Ramachandran S. Vasan, Esteban G. Burchard, Stephanie M. Gogarten, Cecelia Laurie, Thomas W. Blackwell, Gonçalo Abecasis, David J. Carey, Brandon K. Fornwalt, Diane T. Smelser, Aris Baras, Frederick E. Dewey, Cashell E. Jaquish, George J. Papanicolaou, Nona Sotoodehnia, David R. Van Wagoner, Bruce M. Psaty, Sekar Kathiresan, Dawood Darbar, Alvaro Alonso, Susan R. Heckbert, Mina K. Chung, Dan M. Roden, Emelia J. Benjamin, Michael F. Murray, Kathryn L. Lunetta, Steven A. Lubitz & Patrick T. Ellinor, Dec 11 2018, In : JAMA - Journal of the American Medical Association. 320, 22, p. 2354-2364 11 p.

    Research output: Contribution to journalArticle

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