MetroHealth Medical Center

City Cleveland
State Ohio
  1. 2019
  2. Published

    LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase

    Karni S. Moshal, Karim Roder, Anatoli Y. Kabakov, Andreas A. Werdich, David Yi Eng Chiang, Nilüfer N. Turan & 11 others, An Xie, Tae Yun Kim, Leroy L. Cooper, Yichun Lu, Mingwang Zhong, Weiyan Li, Dmitry Terentyev, Bum Rak Choi, Alain Karma, Calum A. Macrae & Gideon Koren, Sep 1 2019, In : Circulation: Genomic and Precision Medicine. 12, 9, p. 407-420 14 p., e002641.

    Research output: Contribution to journalArticle

  3. 2018
  4. Published

    Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity

    Sam Chai, Xiaoping Wan, Angelina Ramirez-Navarro, Paul J. Tesar, Elizabeth S. Kaufman, Eckhard Ficker & 2 others, Alfred L. George & Isabelle Deschênes, Mar 1 2018, In : Journal of Clinical Investigation. 128, 3, p. 1043-1056 14 p.

    Research output: Contribution to journalArticle

  5. Published

    Spectrin-based pathways underlying electrical and mechanical dysfunction in cardiac disease

    Sathya D. Unudurthi, Amara Greer-Short, Nehal Patel, Drew Nassal & Thomas J. Hund, Jan 2 2018, In : Expert review of cardiovascular therapy. 16, 1, p. 59-65 7 p.

    Research output: Contribution to journalReview article

  6. 2017
  7. Published

    Voltage-gated sodium channels assemble and gate as dimers

    Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn & 4 others, Céline Marionneau, Eckhard Ficker, Taekjip Ha & Isabelle Deschênes, Dec 1 2017, In : Nature communications. 8, 1, 2077.

    Research output: Contribution to journalArticle

  8. Published

    KChIP2 regulates the cardiac Ca2+ transient and myocyte contractility by targeting ryanodine receptor activity

    Drew M. Nassal, Xiaoping Wan, Haiyan Liu, Kenneth R. Laurita & Isabelle Deschênes, Apr 2017, In : PloS one. 12, 4, e0175221.

    Research output: Contribution to journalArticle

  9. Published

    KChIP2 is a core transcriptional regulator of cardiac excitability

    Drew M. Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Christine S. Moravec & 3 others, Eckhard Ficker, Kenneth R. Laurita & Isabelle Deschênes, Mar 6 2017, In : eLife. 6, e17304.

    Research output: Contribution to journalArticle

  10. Published

    KChIP2 is a core transcriptional regulator of cardiac excitability

    Drew M. Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Christine S. Moravec & 3 others, Eckhard Ficker, Kenneth R. Laurita & Isabelle Deschênes, Mar 6 2017, In : eLife. 6

    Research output: Contribution to journalArticle

  11. Published

    Contribution of two-pore K+ channels to cardiac ventricular action potential revealed using human iPSC-derived cardiomyocytes

    Sam Chai, Xiaoping Wan, Drew M. Nassal, Haiyan Liu, Christine S. Moravec, Angelina Ramirez-Navarro & 1 others, Isabelle Deschênes, Jan 1 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 6, p. H1144-H1153

    Research output: Contribution to journalArticle

  12. 2016
  13. Published

    Myocardial KChIP2 expression in Guinea pig resolves an expanded electrophysiologic role

    Drew M. Nassal, Xiaoping Wan, Haiyan Liu & Isabelle Deschênes, Jan 1 2016, In : PloS one. 11, 1, e0146561.

    Research output: Contribution to journalArticle

  14. 2015
  15. Published

    Chamber identity programs drive early functional partitioning of the heart

    Christian Mosimann, Daniela Panáková, Andreas A. Werdich, Gabriel Musso, Alexa Burger, Katy L. Lawson & 10 others, Logan A. Carr, Kathleen R. Nevis, M. Khaled Sabeh, Yi Zhou, Alan J. Davidson, Anthony Dibiase, Caroline E. Burns, C. Geoffrey Burns, Calum A. Macrae & Leonard I. Zon, Aug 26 2015, In : Nature communications. 6, 8146.

    Research output: Contribution to journalArticle

  16. 2014
  17. Published

    Brugada syndrome disease phenotype explained in apparently benign sodium channel mutations

    Malcolm Hoshi, Xi X. Du, Krekwit Shinlapawittayatorn, Haiyan Liu, Sam Chai, Xiaoping Wan & 2 others, Eckhard Ficker & Isabelle Deschênes, Apr 2014, In : Circulation: Cardiovascular Genetics. 7, 2, p. 123-131 9 p.

    Research output: Contribution to journalArticle

  18. Published

    Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis

    Shenaz Khan, Bassam G Abu Jawdeh, Monu Goel, William P. Schilling, Mark D. Parker, Michelle A. Puchowicz & 8 others, Satya P. Yadav, Raymond C. Harris, Ashraf El-Meanawy, Malcolm Hoshi, Krekwit Shinlapawittayatorn, Isabelle Deschenes, Eckhard Ficker & Jeffrey R. Schelling, Mar 3 2014, In : Journal of Clinical Investigation. 124, 3, p. 1057-1068 12 p.

    Research output: Contribution to journalArticle

  19. 2013
  20. Published

    Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy

    Anne Karin Arndt, Sebastian Schafer, Jorg Detlef Drenckhahn, M. Khaled Sabeh, Eva R. Plovie, Almuth Caliebe & 19 others, Eva Klopocki, Gabriel Musso, Andreas A. Werdich, Hermann Kalwa, Matthias Heinig, Robert F. Padera, Katharina Wassilew, Julia Bluhm, Christine Harnack, Janine Martitz, Paul J. Barton, Matthias Greutmann, Felix Berger, Norbert Hubner, Reiner Siebert, Hans Heiner Kramer, Stuart A. Cook, Calum A. Macrae & Sabine Klaassen, Jul 11 2013, In : American journal of human genetics. 93, 1, p. 67-77 11 p.

    Research output: Contribution to journalArticle

  21. Published

    Erratum: Wild-type sodium channels and 'Atypical' Brugada syndrome mutants interact through C-terminal region (Biophysical Journal (2013) 104:2 (133a))

    Malcolm Hoshi, Krekwit Shinlapawittayatorn, Sam Chai, Xi X. Du, Haiyan Liu, Xiaoping Wan & 2 others, Eckhard Ficker & Isabelle Deschenes, Apr 16 2013, In : Biophysical journal. 104, 8, 1 p.

    Research output: Contribution to journalComment/debate

  22. 2012
  23. Published

    The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart

    Andreas Augustinus Werdich, Anna Brzezinski, Darwin Jeyaraj, M. Khaled Sabeh, Eckhard Ficker, Xiaoping Wan & 3 others, Brian M. McDermott, Calum Archibald MacRae & David S. Rosenbaum, Oct 1 2012, In : Progress in Biophysics and Molecular Biology. 110, 2-3, p. 154-165 12 p.

    Research output: Contribution to journalArticle

  24. 2011
  25. Published

    Phosphoinositide binding differentially regulates NHE1 Na +/H + exchanger-dependent proximal tubule cell survival

    Bassam G. Abu Jawdeh, Shenaz Khan, Isabelle Desche, Malcolm Hoshi, Monu Goel, Jeffrey T. Lock & 10 others, Krekwit Shinlapawittayatorn, Gerald Babcock, Sujata Lakhe-Reddy, Garren DeCaro, Satya P. Yadav, Maradumane L. Mohan, Sathyamangla V. Naga Prasad, William P. Schilling, Eckhard Ficker & Jeffrey R. Schelling, Dec 9 2011, In : Journal of Biological Chemistry. 286, 49, p. 42435-42445 11 p.

    Research output: Contribution to journalArticle

  26. Published

    A novel strategy using cardiac sodium channel polymorphic fragments to rescue trafficking-deficient SCN5A Mutations

    Krekwit Shinlapawittayatorn, Lynn A. Dudash, Xi X. Du, Lisa Heller, Steven Poelzing, Eckhard Ficker & 1 others, Isabelle Deschênes, Oct 1 2011, In : Circulation: Cardiovascular Genetics. 4, 5, p. 500-509 10 p.

    Research output: Contribution to journalArticle

  27. Published

    The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion

    Jinhu Wang, Daniela Panáková, Kazu Kikuchi, Jennifer E. Holdway, Matthew Philip Gemberling, James S. Burris & 8 others, Sumeet Pal Singh, Amy L. Dickson, Yi Fan Lin, M. Khaled Sabeh, Andreas Augustinus Werdich, Deborah Lynn Yelon, Calum Archibald MacRae & Kenneth Daniel Poss, Aug 15 2011, In : Development. 138, 16, p. 3421-3430 10 p.

    Research output: Contribution to journalArticle

  28. Published

    A common SCN5A polymorphism modulates the biophysical defects of SCN5A mutations

    Krekwit Shinlapawittayatorn, Xi X. Du, Haiyan Liu, Eckhard Ficker, Elizabeth S. Kaufman & Isabelle Deschênes, Mar 1 2011, In : Heart Rhythm. 8, 3, p. 455-462 8 p.

    Research output: Contribution to journalArticle

  29. 2010
  30. Published

    Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes

    Kazu Kikuchi, Jennifer E. Holdway, Andreas A. Werdich, Ryan M. Anderson, Yi Fang, Gregory F. Egnaczyk & 4 others, Todd Evans, Calum A. MacRae, Didier Y.R. Stainier & Kenneth D. Poss, Mar 25 2010, In : Nature. 464, 7288, p. 601-605 5 p.

    Research output: Contribution to journalArticle