Gloria C Ferreira

Person

  1. 2019
  2. Published

    5-Aminolevulinate synthase catalysis: The catcher in heme biosynthesis

    Bosko M. Stojanovski, Gregory A. Hunter, Insung Na, Vladimir N. Uversky, Rays H.Y. Jiang & Gloria C. Ferreira, Nov 2019, In : Molecular Genetics and Metabolism. 128, 3, p. 178-189 12 p.

    Research output: Contribution to journalReview article

  3. 2018
  4. Published

    Ferrochelatase π-helix: Implications from examining the role of the conserved π-helix glutamates in porphyrin metalation and product release

    Mallory E. Gillam, Gregory A. Hunter & Gloria C. Ferreira, Apr 15 2018, In : Archives of Biochemistry and Biophysics. 644, p. 37-46 10 p.

    Research output: Contribution to journalArticle

  5. 2017
  6. Published

    Isoniazid inhibits human erythroid 5-aminolevulinate synthase: Molecular mechanism and tolerance study with four X-linked protoporphyria patients

    Erica J. Fratz-Berilla, Leonid Breydo, Laurent Gouya, Hervé Puy, Vladimir N. Uversky & Gloria C. Ferreira, Feb 1 2017, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1863, 2, p. 428-439 12 p.

    Research output: Contribution to journalArticle

  7. 2016
  8. Published

    The unfolding pathways of the native and molten globule states of 5-aminolevulinate synthase

    Bosko M. Stojanovski, Leonid Breydo, Vladimir N. Uversky & Gloria C Ferreira, Nov 18 2016, In : Biochemical and Biophysical Research Communications. 480, 3, p. 321-327 7 p.

    Research output: Contribution to journalArticle

  9. Published

    The structure of the complex between yeast frataxin and ferrochelatase: Characterization and pre-steady state reaction of ferrous iron delivery and heme synthesis

    Christopher Söderberg, Mallory E. Gillam, Eva Christina Ahlgren, Gregory A. Hunter, Oleksandr Gakh, Grazia Isaya & 2 others, Gloria C. Ferreira & Salam Al-Karadaghi, May 27 2016, In : Journal of Biological Chemistry. 291, 22, p. 11887-11898 12 p.

    Research output: Contribution to journalArticle

  10. Published

    Murine erythroid 5-aminolevulinate synthase: Truncation of a disordered N-terminal extension is not detrimental for catalysis

    Bosko M. Stojanovski, Leonid Breydo, Vladimir N. Uversky & Gloria C Ferreira, May 1 2016, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1864, 5, p. 441-452 12 p.

    Research output: Contribution to journalArticle

  11. Published

    The conserved active site histidine-glutamate pair of ferrochelatase coordinately catalyzes porphyrin metalation

    Gregory A. Hunter, Sai Lakshmana Vankayala, Mallory E. Gillam, Fiona L. Kearns, H. Lee Woodcock & Gloria C. Ferreira, Apr 1 2016, In : Journal of Porphyrins and Phthalocyanines. 20, 1-4, p. 556-569 14 p.

    Research output: Contribution to journalArticle

  12. Published

    Macromolecular crowders and osmolytes modulate the structural and catalytic properties of alkaline molten globular 5-aminolevulinate synthase

    Bosko M. Stojanovski, Leonid Breydo, Vladimir N. Uversky & Gloria C. Ferreira, Jan 1 2016, In : RSC Advances. 6, 115, p. 114541-114552 12 p.

    Research output: Contribution to journalArticle

  13. 2015
  14. Published

    Asn-150 of murine erythroid 5-aminolevulinate synthase modulates the catalytic balance between the rates of the reversible reaction

    Bosko M. Stojanovski & Gloria C. Ferreira, Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30750-30761 12 p.

    Research output: Contribution to journalArticle

  15. Published

    Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release

    Erica J. Fratz, Jerome Clayton, Gregory A. Hunter, Sarah Ducamp, Leonid Breydo, Vladimir N. Uversky & 4 others, Jean Charles Deybach, Laurent Gouya, Hervé Puy & Gloria C. Ferreira, Sep 15 2015, In : Biochemistry. 54, 36, p. 5617-5631 15 p.

    Research output: Contribution to journalArticle

  16. Published

    Murine erythroid 5-aminolevulinate synthase: Adenosyl-binding site Lys221 modulates substrate binding and catalysis

    Bosko M. Stojanovski & Gloria C. Ferreira, Sep 1 2015, In : FEBS Open Bio. 5, p. 824-831 8 p.

    Research output: Contribution to journalArticle

  17. 2014
  18. Published

    Catalytically active alkaline molten globular enzyme: Effect of pH and temperature on the structural integrity of 5-aminolevulinate synthase

    Bosko M. Stojanovski, Leonid Breydo, Gregory A. Hunter, Vladimir N. Uversky & Gloria C. Ferreira, Dec 2014, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1844, 12, p. 2145-2154 10 p.

    Research output: Contribution to journalArticle

  19. Published

    Unstable reaction intermediates and hysteresis during the catalytic cycle of 5-aminolevulinate synthase: Implications from using pseudo and alternate substrates and a promiscuous enzyme variant

    Bosko M. Stojanovski, Gregory A. Hunter, Martina Jahn, Dieter Jahn & Gloria C Ferreira, Aug 15 2014, In : Journal of Biological Chemistry. 289, 33, p. 22915-22925 11 p.

    Research output: Contribution to journalArticle

  20. Published

    Expression of murine 5-aminolevulinate synthase variants causes protoporphyrin IX accumulation and light-induced mammalian cell death

    Erica J. Fratz, Gregory A. Hunter & Gloria C. Ferreira, Apr 9 2014, In : PloS one. 9, 4, e93078.

    Research output: Contribution to journalArticle

  21. 2013
  22. Published

    Aminolaevulinic acid synthase of rhodobacter capsulatus: High-resolution kinetic investigation of the structural basis for substrate binding and catalysis

    Anna Lena Kaufholz, Gregory A. Hunter, Gloria C Ferreira, Thomas Lendrihas, Vanessa Hering, Gunhild Layer & 2 others, Martina Jahn & Dieter Jahn, Apr 15 2013, In : Biochemical Journal. 451, 2, p. 205-216 12 p.

    Research output: Contribution to journalArticle

  23. Published

    Molecular and functional analysis of the C-terminal region of human erythroid-specific 5-aminolevulinic synthase associated with X-linked dominant protoporphyria (XLDPP)

    Sarah Ducamp, Xiaoye Schneider-Yin, Felix De Rooij, Jerome Clayton, Erica J. Fratz, Alice Rudd & 9 others, George Ostapowicz, George Varigos, Thibaud Lefebvre, Jean Charles Deybach, Laurent Gouya, Paul Wilson, Gloria C. Ferreira, Elisabeth I. Minder & Hervé Puy, Apr 1 2013, In : Human molecular genetics. 22, 7, p. 1280-1288 9 p., dds531.

    Research output: Contribution to journalArticle

  24. 2011
  25. Published

    Molecular enzymology of 5-Aminolevulinate synthase, the gatekeeper of heme biosynthesis

    Gregory A. Hunter & Gloria C. Ferreira, Nov 1 2011, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1814, 11, p. 1467-1473 7 p.

    Research output: Contribution to journalReview article

  26. Published

    ALAS2 acts as a modifier gene in patients with congenital erythropoietic porphyria

    Jordi To-Figueras, Sarah Ducamp, Jerome Clayton, Celia Badenas, Constance Delaby, Cecile Ged & 8 others, Said Lyoumi, Laurent Gouya, Hubert De Verneuil, Carole Beaumont, Gloria C. Ferreira, Jean Charles Deybach, Carmen Herrero & Herve Puy, Aug 11 2011, In : Blood. 118, 6, p. 1443-1451 9 p.

    Research output: Contribution to journalArticle

  27. Published

    Functional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase

    Tracy D. Turbeville, Junshun Zhang, W. Christopher Adams, Gregory A. Hunter & Gloria C. Ferreira, Jul 1 2011, In : Archives of Biochemistry and Biophysics. 511, 1-2, p. 107-117 11 p.

    Research output: Contribution to journalArticle

  28. Published

    Ferrochelatase: The convergence of the porphyrin biosynthesis and iron transport pathways

    Gregory A. Hunter, Salam Al-Karadaghi & Gloria C. Ferreira, Jan 1 2011, In : Journal of Porphyrins and Phthalocyanines. 15, 5-6, p. 350-356 7 p.

    Research output: Contribution to journalArticle