Helen Waldschmidt

Person

  1. 2019
  2. Published

    Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors

    Rachel A. Rowlands, M. Claire Cato, Helen V. Waldschmidt, Renee A. Bouley, Qiuyan Chen, Larisa Avramova & 3 others, Scott D. Larsen, John J.G. Tesmer & Andrew D. White, Dec 12 2019, In : ACS Medicinal Chemistry Letters. 10, 12, p. 1628-1634 7 p.

    Research output: Contribution to journalArticle

  3. Published

    Correction to: Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine (Journal of Medicinal Chemistry (2017) 60:7 (3052-3069) DOI: 10.1021/acs.jmedchem.7b00112)

    Helen Waldschmidt, Kristoff Theodor Homan, Marilyn C. Cato, Osvaldo Cruz-Rodríguez, Alessandro Cannavo, Michael W. Wilson & 5 others, Jianliang Song, Joseph Y Cheung, Walter J Koch, John J.G. Tesmer & Scott D. Larsen, Jun 27 2019, In : Journal of Medicinal Chemistry. 62, 12, 1 p.

    Research output: Contribution to journalComment/debate

  4. 2018
  5. Published

    Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors

    Helen V. Waldschmidt, Renee Bouley, Paul D. Kirchhoff, Pil Lee, John J.G. Tesmer & Scott D. Larsen, May 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 9, p. 1507-1515 9 p.

    Research output: Contribution to journalArticle

  6. 2017
  7. Published

    Structural determinants influencing the potency and selectivity of indazole-paroxetine hybrid G protein-coupled receptor kinase 2 inhibitors

    Renee Bouley, Helen V. Waldschmidt, M. Claire Cato, Alessandro Cannavo, Jianliang Song, Joseph Y. Cheung & 4 others, Xin Qiu Yao, Walter J. Koch, Scott D. Larsen & John J.G. Tesmer, Dec 2017, In : Molecular pharmacology. 92, 6, p. 707-717 11 p.

    Research output: Contribution to journalArticle

  8. Published

    Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine

    Helen V. Waldschmidt, Kristoff T. Homan, Marilyn C. Cato, Osvaldo Cruz-Rodríguez, Alessandro Cannavo, Michael W. Wilson & 5 others, Jianliang Song, Joseph Y. Cheung, Walter J. Koch, John J.G. Tesmer & Scott D. Larsen, Apr 13 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 3052-3069 18 p.

    Research output: Contribution to journalArticle

  9. 2016
  10. Published

    Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors

    Helen V. Waldschmidt, Kristoff T. Homan, Osvaldo Cruz-Rodríguez, Marilyn C. Cato, Jessica Waninger-Saroni, Kelly M. Larimore & 7 others, Alessandro Cannavo, Jianliang Song, Joseph Y. Cheung, Paul D. Kirchhoff, Walter J. Koch, John J.G. Tesmer & Scott D. Larsen, Apr 28 2016, In : Journal of Medicinal Chemistry. 59, 8, p. 3793-3807 15 p.

    Research output: Contribution to journalArticle

  11. 2015
  12. Published

    Crystal structure of G protein-coupled receptor kinase 5 in complex with a rationally designed inhibitor

    Kristoff T. Homan, Helen V. Waldschmidt, Alisa Glukhova, Alessandro Cannavo, Jianliang Song, Joseph Y. Cheung & 3 others, Walter J. Koch, Scott D. Larsen & John J.G. Tesmer, Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 20649-20659 11 p.

    Research output: Contribution to journalArticle