Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes

Research output: Contribution to journalArticle

Authors

  • VISTA-ICH Steering Committee Collaborators

External Institution(s)

  • Weill Cornell Medical College
  • Cornell University
  • Harvard University
  • Yale University
  • Columbia University
  • Department of Veterans Affairs
  • Johns Hopkins University

Details

Original languageEnglish (US)
Pages (from-to)3057-3063
Number of pages7
JournalStroke
Volume50
Issue number11
StatusPublished - Nov 1 2019
Peer-reviewedYes

Abstract

Background and Purpose- Observational data suggest that antiplatelet therapy after intracerebral hemorrhage (ICH) alleviates thromboembolic risk without increasing the risk of recurrent ICH. Given the paucity of data on the relationship between antiplatelet therapy after ICH and functional outcomes, we aimed to study this association in a multicenter cohort. Methods- We meta-analyzed data from (1) the Massachusetts General Hospital ICH registry (n=1854), (2) the Virtual International Stroke Trials Archive database (n=762), and (3) the Yale stroke registry (n=185). Our exposure was antiplatelet therapy after ICH, which was modeled as a time-varying covariate. Our primary outcomes were all-cause mortality and a composite of major disability or death (modified Rankin Scale score 4-6). We used Cox proportional regression analyses to estimate the hazard ratio of death or poor functional outcome as a function of antiplatelet therapy and random-effects meta-analysis to pool the estimated HRs across studies. Additional analyses stratified by hematoma location (lobar and deep ICH) were performed. Results- We included a total of 2801 ICH patients, of whom 288 (10.3%) were started on antiplatelet medications after ICH. Median times to antiplatelet therapy ranged from 7 to 39 days. Antiplatelet therapy after ICH was not associated with mortality (hazard ratio, 0.85; 95% CI, 0.66-1.09), or death or major disability (hazard ratio, 0.83; 95% CI, 0.59-1.16) compared with patients not started on antiplatelet therapy. Similar results were obtained in additional analyses stratified by hematoma location. Conclusions- Antiplatelet therapy after ICH appeared safe and was not associated with all-cause mortality or functional outcome, regardless of hematoma location. Randomized clinical trials are needed to determine the effects and harms of antiplatelet therapy after ICH.

    Research areas

  • cerebral hemorrhage, mortality, platelet aggregation inhibitors, stroke

Citation formats

APA

Harvard

VISTA-ICH Steering Committee Collaborators 2019, 'Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes', Stroke, vol. 50, no. 11, pp. 3057-3063. https://doi.org/10.1161/STROKEAHA.119.025972