Application and Evaluation of Highly Automated Software for Comprehensive Stent Analysis in Intravascular Optical Coherence Tomography

Research output: Contribution to journalArticle

Authors

  • Hong Lu
  • Juhwan Lee
  • Martin Jakl
  • Zhao Wang
  • Pavel Cervinka
  • Hiram G. Bezerra
  • David L. Wilson

External Institution(s)

  • Microsoft Research Asia
  • Case Western Reserve University
  • Charles University
  • Massachusetts Institute of Technology
  • Jan Evangelista Purkyne University in Usti nad Labem

Details

Original languageEnglish (US)
Article number2150
JournalScientific reports
Volume10
Issue number1
StatusPublished - Dec 1 2020
Peer-reviewedYes

Abstract

Intravascular optical coherence tomography (IVOCT) is used to assess stent tissue coverage and malapposition in stent evaluation trials. We developed the OCT Image Visualization and Analysis Toolkit for Stent (OCTivat-Stent), for highly automated analysis of IVOCT pullbacks. Algorithms automatically detected the guidewire, lumen boundary, and stent struts; determined the presence of tissue coverage for each strut; and estimated the stent contour for comparison of stent and lumen area. Strut-level tissue thickness, tissue coverage area, and malapposition area were automatically quantified. The software was used to analyze 292 stent pullbacks. The concordance-correlation-coefficients of automatically measured stent and lumen areas and independent manual measurements were 0.97 and 0.99, respectively. Eleven percent of struts were missed by the software and some artifacts were miscalled as struts giving 1% false-positive strut detection. Eighty-two percent of uncovered struts and 99% of covered struts were labeled correctly, as compared to manual analysis. Using the highly automated software, analysis was harmonized, leading to a reduction of inter-observer variability by 30%. With software assistance, analysis time for a full stent analysis was reduced to less than 30 minutes. Application of this software to stent evaluation trials should enable faster, more reliable analysis with improved statistical power for comparing designs.

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