Associations of awake and asleep blood pressure and blood pressure dipping with abnormalities of cardiac structure: The Coronary Artery Risk Development in Young Adults study

Research output: Contribution to journalArticle

Authors

  • Natalie A. Bello
  • Byron C. Jaeger
  • John N. Booth
  • Marwah Abdalla
  • D. Edmund Anstey
  • Daniel N. Pugliese
  • Cora E. Lewis
  • Samuel S. Gidding
  • Donald Lloyd-Jones
  • Sanjiv J. Shah
  • Joseph E. Schwartz
  • James M. Shikany
  • Paul Muntner
  • Daichi Shimbo

External Institution(s)

  • Columbia University
  • Department of Biostatistics
  • Department of Epidemiology
  • The Familial Hypercholesterolemia Foundation
  • Department of Preventive Medicine
  • Stony Brook University
  • University of Alabama at Birmingham

Details

Original languageEnglish (US)
Pages (from-to)102-110
Number of pages9
JournalJournal of hypertension
Volume38
Issue number1
StatusPublished - Jan 1 2020
Peer-reviewedYes

Abstract

Objectives:To evaluate the associations of high awake blood pressure (BP), high asleep BP, and nondipping BP, determined by ambulatory BP monitoring (ABPM), with left ventricular hypertrophy (LVH) and geometry.Methods:Black and white participants (n = 687) in the Coronary Artery Risk Development in Young Adults study underwent 24-h ABPM and echocardiography at the Year 30 Exam in 2015-2016. The prevalence and prevalence ratios of LVH were calculated for high awake SBP (≥130 mmHg), high asleep SBP (≥110 mmHg), the cross-classification of high awake and asleep SBP, and nondipping SBP (percentage decline in awake-to-asleep SBP < 10%). Odds ratios for abnormal left ventricular geometry associated with these phenotypes were calculated.Results:Overall, 46.0 and 49.1% of study participants had high awake and asleep SBP, respectively, and 31.1% had nondipping SBP. After adjustment for demographics and clinical characteristics, high awake SBP was associated with a prevalence ratio for LVH of 2.79 [95% confidence interval (95% CI) 1.63-4.79]. High asleep SBP was also associated with a prevalence ratio for LVH of 2.19 (95% CI 1.25-3.83). There was no evidence of an association between nondipping SBP and LVH (prevalence ratio 0.70, 95% CI 0.44-1.12). High awake SBP with or without high asleep SBP was associated with a higher odds ratio of concentric remodeling and hypertrophy.Conclusion:Awake and asleep SBP, but not the decline in awake-to-asleep SBP, were associated with increased prevalence of cardiac end-organ damage.

    Research areas

  • ambulatory blood pressure monitoring, left ventricular hypertrophy, left ventricular remodeling, nondipping blood pressure, target organ damage

Citation formats

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Bello, NA, Jaeger, BC, Booth, JN, Abdalla, M, Anstey, DE, Pugliese, DN, Lewis, CE, Gidding, SS, Lloyd-Jones, D, Shah, SJ, Schwartz, JE, Shikany, JM, Muntner, P & Shimbo, D 2020, 'Associations of awake and asleep blood pressure and blood pressure dipping with abnormalities of cardiac structure: The Coronary Artery Risk Development in Young Adults study', Journal of hypertension, vol. 38, no. 1, pp. 102-110. https://doi.org/10.1097/HJH.0000000000002221