Autocatalytic Delivery of Brain Tumor–Targeting, Size-Shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases

Research output: Contribution to journalArticle

Authors

  • Shenqi Zhang
  • Gang Deng
  • Fuyao Liu
  • Bin Peng
  • Youmei Bao
  • Fengyi Du
  • Ann T. Chen
  • Jun Liu
  • Zeming Chen
  • Junning Ma
  • Xiangjun Tang
  • Qianxue Chen
  • Jiangbing Zhou

External Institution(s)

  • Yale University
  • Wuhan University

Details

Original languageEnglish (US)
Article number1910651
JournalAdvanced Functional Materials
Volume30
Issue number14
StatusPublished - Apr 1 2020
Peer-reviewedYes

Abstract

Breast cancer brain metastases (BCBMs) represent a major cause of morbidity and mortality among patients with breast cancer. Chemotherapy, which is widely used to treat tumors outside of the brain, is often ineffective on BCBMs due to its inability to efficiently cross the blood-brain barrier (BBB). Although the BBB is partially disrupted in tumor lesions, it remains intact enough to prevent most therapeutics from entering the brain. Here, a nanotechnology approach is reported that can overcome the BBB through synthesis of lexiscan-loaded, AMD3100-conjugated, shrinkable nanoparticles (NPs), or LANPs. LANPs respond to neutrophil elastase–enriched tumor microenvironment by shrinking in size and disrupt the BBB in tumors through lexiscan-mediated modulation. LANPs recognize tumor cells through the interaction between AMD3100 and CXCR4, which are expressed in metastatic tumor cells. The integration of tumor responsiveness, tumor targeting, and BBB penetration that enables LANPs to penetrate metastatic lesions in the brain with high efficiency is demonstrated and, when doxorubicin is encapsulated, LANPs effectively inhibit tumor growth and prolong the survival of tumor-bearing mice. Due to their high efficiency in penetrating the BBB for BCBMs treatment, LANPs have the potential to be translated into clinical applications for improved treatment of patients with BCBMs.

    Research areas

  • CXCR4, blood-brain barrier, breast cancer brain metastases, neutrophil elastase, shrinkable nanoparticles

Citation formats

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Zhang, S, Deng, G, Liu, F, Peng, B, Bao, Y, Du, F, Chen, AT, Liu, J, Chen, Z, Ma, J, Tang, X, Chen, Q & Zhou, J 2020, 'Autocatalytic Delivery of Brain Tumor–Targeting, Size-Shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases', Advanced Functional Materials, vol. 30, no. 14, 1910651. https://doi.org/10.1002/adfm.201910651