Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure

Research output: Contribution to journalReview article

Authors

External Institution(s)

  • University of Virginia

Details

Original languageEnglish (US)
Pages (from-to)196-207
Number of pages12
JournalJACC: Basic to Translational Science
Volume5
Issue number2
StatusPublished - Feb 2020
Peer-reviewedYes

Abstract

Heart failure is a common disease with poor prognosis that is associated with cardiac immune cell infiltration and dysregulated cytokine expression. Recently, the clonal expansion of hematopoietic cells with acquired (i.e., nonheritable) DNA mutations, a process referred to as clonal hematopoiesis, has been reported to be associated with cardiovascular diseases including heart failure. Mechanistic studies have shown that leukocytes that harbor these somatic mutations display altered inflammatory characteristics that worsen the phenotypes associated with heart failure in experimental models. In this review, we summarize recent epidemiological and experimental evidence that support the hypothesis that clonal hematopoiesis-mediated immune cell dysfunction contributes to heart failure and cardiovascular disease in general.

    Research areas

  • DNMT3A, Il-1β inflammasome, JAK2, TET2, TNF-α

Citation formats

APA

Yura, Y., Sano, S., & Walsh, K. (2020). Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure. JACC: Basic to Translational Science, 5(2), 196-207. https://doi.org/10.1016/j.jacbts.2019.08.006

Harvard

Yura, Y, Sano, S & Walsh, K 2020, 'Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure', JACC: Basic to Translational Science, vol. 5, no. 2, pp. 196-207. https://doi.org/10.1016/j.jacbts.2019.08.006