Delta-like ligand 4-notch signaling in macrophage activation

Research output: Contribution to journalReview article

Authors

External Institution(s)

  • Harvard University

Details

Original languageEnglish (US)
Pages (from-to)2038-2047
Number of pages10
JournalArteriosclerosis, thrombosis, and vascular biology
Volume36
Issue number10
StatusPublished - Oct 1 2016
Peer-reviewedYes

Abstract

The Notch signaling pathway regulates the development of various cell types and organs, and also contributes to disease mechanisms in adults. Accumulating evidence suggests its role in cardiovascular and metabolic diseases. Notch signaling components also control the phenotype of immune cells. Delta-like ligand 4 (Dll4) of the Notch pathway promotes proinflammatory activation of macrophages in vitro and in vivo. Dll4 blockade attenuates chronic atherosclerosis, vein graft disease, vascular calcification, insulin resistance, and fatty liver in mice. The Dll4-Notch axis may, thus, participate in the shared mechanisms for cardiometabolic disorders, serving as a potential therapeutic target for ameliorating these global health problems.

    Research areas

  • atherosclerosis, fatty liver, inflammation, macrophage, metabolic disease, veins

Citation formats

APA

Nakano, T., Fukuda, D., Koga, J. I., & Aikawa, M. (2016). Delta-like ligand 4-notch signaling in macrophage activation. Arteriosclerosis, thrombosis, and vascular biology, 36(10), 2038-2047. https://doi.org/10.1161/ATVBAHA.116.306926

Harvard

Nakano, T, Fukuda, D, Koga, JI & Aikawa, M 2016, 'Delta-like ligand 4-notch signaling in macrophage activation', Arteriosclerosis, thrombosis, and vascular biology, vol. 36, no. 10, pp. 2038-2047. https://doi.org/10.1161/ATVBAHA.116.306926