Dl-3-n-butylphthalide reduces neurovascular inflammation and ischemic brain injury in mice

Research output: Contribution to journalArticle

Authors

  • Chun Sheng Yang
  • Ai Guo
  • Yulin Li
  • Kaibin Shi
  • Fu Dong Shi
  • Minshu Li

External Institution(s)

  • Tianjin Medical University
  • St. Joseph's Hospital and Medical Center

Details

Original languageEnglish (US)
Pages (from-to)964-976
Number of pages13
JournalAging and Disease
Volume10
Issue number5
StatusPublished - Jan 1 2019
Peer-reviewedYes

Abstract

Dl-3-n-butylphthalide (NBP) is a synthetic compound that has been approved for the treatment of ischemic stroke in China. The mechanisms underlying the treatment efficacy of NBP have been reported in multiple studies and remain controversial. Here, we show that NBP treatment attenuated ischemic brain injury in mice subjected to transient middle cerebral artery occlusion or photothrombosis-induced permanent cerebral ischemia. NBP induced downregulation of intercellular adhesion molecule 1 and protease-activated receptor 1 in cerebrovascular endothelial cells after cerebral ischemia and reperfusion. This effect was associated with the reduced brain infiltration of myeloid cells and improved cerebral blood flow after reperfusion. The beneficial effects of NBP were diminished in mice subjected to the depletion of Gr1+ myeloid cells before brain ischemia. Therefore, the restriction of neurovascular inflammation is a key mode of action for NBP in ischemic stroke.

    Research areas

  • Dl-3-n-butylphthalide, Ischemic stroke, Neuroinflammation, Neurovascular unit

Citation formats

APA

Yang, C. S., Guo, A., Li, Y., Shi, K., Shi, F. D., & Li, M. (2019). Dl-3-n-butylphthalide reduces neurovascular inflammation and ischemic brain injury in mice. Aging and Disease, 10(5), 964-976. https://doi.org/10.14336/AD.2019.0608

Harvard

Yang, CS, Guo, A, Li, Y, Shi, K, Shi, FD & Li, M 2019, 'Dl-3-n-butylphthalide reduces neurovascular inflammation and ischemic brain injury in mice', Aging and Disease, vol. 10, no. 5, pp. 964-976. https://doi.org/10.14336/AD.2019.0608