Energy Trade-offs in Host Defense: Immunology Meets Physiology
Research output: Contribution to journal › Short survey
- St. Joseph's Hospital and Medical Center
Host defense relies not only on microbicidal mechanisms (resistance), but also on management of collateral damage (tolerance). Here, we discuss how this immunology concept converges with a physiology-born theory on the dichotomy of thermometabolic responses in infection (fever versus hypothermia), yielding a model of immunity that transcends discipline barriers.
- fever, hypothermia, immunity, inflammation, resistance, tolerance