Fully automated plaque characterization in intravascular OCT images using hybrid convolutional and lumen morphology features

Research output: Contribution to journalArticle

Authors

  • Juhwan Lee
  • David Prabhu
  • Chaitanya Kolluru
  • Yazan Gharaibeh
  • Vladislav N. Zimin
  • Luis A.P. Dallan
  • Hiram G. Bezerra
  • David L. Wilson

External Institution(s)

  • Case Western Reserve University

Details

Original languageEnglish (US)
Article number2596
JournalScientific reports
Volume10
Issue number1
StatusPublished - Dec 1 2020
Peer-reviewedYes

Abstract

For intravascular OCT (IVOCT) images, we developed an automated atherosclerotic plaque characterization method that used a hybrid learning approach, which combined deep-learning convolutional and hand-crafted, lumen morphological features. Processing was done on innate A-line units with labels fibrolipidic (fibrous tissue followed by lipidous tissue), fibrocalcific (fibrous tissue followed by calcification), or other. We trained/tested on an expansive data set (6,556 images), and performed an active learning, relabeling step to improve noisy ground truth labels. Conditional random field was an important post-processing step to reduce classification errors. Sensitivities/specificities were 84.8%/97.8% and 91.4%/95.7% for fibrolipidic and fibrocalcific plaques, respectively. Over lesions, en face classification maps showed automated results that agreed favorably to manually labeled counterparts. Adding lumen morphological features gave statistically significant improvement (p < 0.05), as compared to classification with convolutional features alone. Automated assessments of clinically relevant plaque attributes (arc angle and length), compared favorably to those from manual labels. Our hybrid approach gave statistically improved results as compared to previous A-line classification methods using deep learning or hand-crafted features alone. This plaque characterization approach is fully automated, robust, and promising for live-time treatment planning and research applications.

Citation formats

APA

Lee, J., Prabhu, D., Kolluru, C., Gharaibeh, Y., Zimin, V. N., Dallan, L. A. P., ... Wilson, D. L. (2020). Fully automated plaque characterization in intravascular OCT images using hybrid convolutional and lumen morphology features. Scientific reports, 10(1), [2596]. https://doi.org/10.1038/s41598-020-59315-6

Harvard

Lee, J, Prabhu, D, Kolluru, C, Gharaibeh, Y, Zimin, VN, Dallan, LAP, Bezerra, HG & Wilson, DL 2020, 'Fully automated plaque characterization in intravascular OCT images using hybrid convolutional and lumen morphology features', Scientific reports, vol. 10, no. 1, 2596. https://doi.org/10.1038/s41598-020-59315-6