Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

Research output: Contribution to journalArticle


  • Caren E. Smith
  • Jack L. Follis
  • Hassan S. Dashti
  • Toshiko Tanaka
  • Mariaelisa Graff
  • Amanda M. Fretts
  • Tuomas O. Kilpeläinen
  • Mary K. Wojczynski
  • Kris Richardson
  • Mike A. Nalls
  • Christina Alexandra Schulz
  • Yongmei Liu
  • Esther van Eekelen
  • Carol Wang
  • Vera Mikkilä
  • Rebecca Rohde
  • Bruce M. Psaty
  • Torben Hansen
  • Mary F. Feitosa
  • Chao Qiang Lai
  • Denise K. Houston
  • Luigi Ferruci
  • Ulrika Ericson
  • Zhe Wang
  • Renée de Mutsert
  • Wendy H. Oddy
  • Ester A.L. de Jonge
  • Ilkka Seppälä
  • Rozenn N. Lemaitre
  • Thorkild I.A. Sørensen
  • Michael A. Province
  • Laurence D. Parnell
  • Melissa E. Garcia
  • Stefania Bandinelli
  • Marju Orho-Melander
  • Stephen S. Rich
  • Frits R. Rosendaal
  • Craig E. Pennell
  • Jessica C. Kiefte-de Jong
  • Mika Kähönen
  • Kristin L. Young
  • Oluf Pedersen
  • Jerome I. Rotter
  • Dennis O. Mook-Kanamori
  • M. Carola Zillikens
  • Olli T. Raitakari
  • Kim Overvad
  • Albert Hofman
  • Terho Lehtimäki
  • Anne Tjønneland
  • André G. Uitterlinden
  • Fernando Rivadeneira
  • Oscar H. Franco
  • J. Bruce German
  • David S. Siscovick
  • L. Adrienne Cupples
  • José M. Ordovás

External Institution(s)

  • Tufts University
  • University of St. Thomas
  • Harvard University
  • Broad Institute
  • National Institutes of Health
  • University of North Carolina at Chapel Hill
  • University of Washington
  • University of Copenhagen
  • Washington University St. Louis
  • Contractor/consultant with Kelly Services
  • Lund University Diabetes Centre
  • Wake Forest University
  • Leiden University
  • University of Western Australia
  • University of Helsinki
  • University of Turku
  • Group Health Cooperative
  • University of Texas Health Science Center at Houston
  • University of Tasmania
  • Erasmus University Rotterdam
  • Tampere University
  • University of Bristol
  • National Institute of Aging
  • Geriatric Unit Azienda Sanitaria di Firenze
  • University of Virginia
  • University of California at Los Angeles
  • Aarhus University
  • Aalborg University
  • Danish Cancer Society
  • Netherlands Genomics Initiative
  • University of California at Davis
  • New York Academy of Medicine
  • Boston University
  • Instituto de Salud Carlos III
  • IMDEA Food Institute


Original languageEnglish (US)
Article number1700347
JournalMolecular Nutrition and Food Research
Issue number3
StatusPublished - Feb 1 2018


Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10−7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10−8) such that each serving of low-fat dairy was associated with 0.225 kg m−2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.

    Research areas

  • CHARGE consortium, body mass index, dairy intake, genome-wide interaction study, meta-analysis

Citation formats


Smith, C. E., Follis, J. L., Dashti, H. S., Tanaka, T., Graff, M., Fretts, A. M., ... Ordovás, J. M. (2018). Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. Molecular Nutrition and Food Research, 62(3), [1700347].


Smith, CE, Follis, JL, Dashti, HS, Tanaka, T, Graff, M, Fretts, AM, Kilpeläinen, TO, Wojczynski, MK, Richardson, K, Nalls, MA, Schulz, CA, Liu, Y, Frazier-Wood, AC, van Eekelen, E, Wang, C, de Vries, PS, Mikkilä, V, Rohde, R, Psaty, BM, Hansen, T, Feitosa, MF, Lai, CQ, Houston, DK, Ferruci, L, Ericson, U, Wang, Z, de Mutsert, R, Oddy, WH, de Jonge, EAL, Seppälä, I, Justice, AE, Lemaitre, RN, Sørensen, TIA, Province, MA, Parnell, LD, Garcia, ME, Bandinelli, S, Orho-Melander, M, Rich, SS, Rosendaal, FR, Pennell, CE, Kiefte-de Jong, JC, Kähönen, M, Young, KL, Pedersen, O, Aslibekyan, S, Rotter, JI, Mook-Kanamori, DO, Zillikens, MC, Raitakari, OT, North, KE, Overvad, K, Arnett, DK, Hofman, A, Lehtimäki, T, Tjønneland, A, Uitterlinden, AG, Rivadeneira, F, Franco, OH, German, JB, Siscovick, DS, Cupples, LA & Ordovás, JM 2018, 'Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent', Molecular Nutrition and Food Research, vol. 62, no. 3, 1700347.