Global brain inflammation in stroke

Research output: Contribution to journalReview article


  • Kaibin Shi
  • De Cai Tian
  • Zhi Guo Li
  • Andrew F. Ducruet
  • Michael T. Lawton
  • Fu Dong Shi

External Institution(s)

  • Tianjin Medical University
  • St. Joseph's Hospital and Medical Center
  • Capital Medical University


Original languageEnglish (US)
Pages (from-to)1058-1066
Number of pages9
JournalThe Lancet Neurology
Issue number11
StatusPublished - Nov 2019


Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal cell death and the release of factors such as damage-associated molecular patterns (DAMPs) that elicit localised inflammation in the injured brain region. Such focal brain inflammation aggravates secondary brain injury by exacerbating blood–brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death. In addition to inflammation localised to the injured brain region, a growing body of evidence suggests that inflammatory responses after a stroke occur and persist throughout the entire brain. Global brain inflammation might continuously shape the evolving pathology after a stroke and affect the patients' long-term neurological outcome. Future efforts towards understanding the mechanisms governing the emergence of so-called global brain inflammation would facilitate modulation of this inflammation as a potential therapeutic strategy for stroke.

Citation formats


Shi, K., Tian, D. C., Li, Z. G., Ducruet, A. F., Lawton, M. T., & Shi, F. D. (2019). Global brain inflammation in stroke. The Lancet Neurology, 18(11), 1058-1066.


Shi, K, Tian, DC, Li, ZG, Ducruet, AF, Lawton, MT & Shi, FD 2019, 'Global brain inflammation in stroke', The Lancet Neurology, vol. 18, no. 11, pp. 1058-1066.