Research output: Chapter in Book/Report/Conference proceeding › Chapter
- LSU Health Sciences Center - Shreveport
- Lakeland Community College
Herpesviruses are highly prevalent viruses that establish a lifelong persistent infection in the host. It was thought most immunocompetent individuals do not succumb to overt virus-associated disease, but evidence is building that herpesviruses may contribute to many disease states previously not associated with these viruses, including vascular diseases. This chapter will review the available literature on this link, with particular emphasis on the mechanisms underlying how herpesviruses promote vascular dysfunction, immune dysregulation, and platelet activation. Because most of the published data on this topic relate to cytomegalovirus, we will focus primarily on this member of the herpesvirus family, with reference to the other members throughout. Finally, how the viruses may impact other risk factors will be summarized.
- Cardiovascular disease, Cytokines, Cytomegalovirus, Endothelial dysfunction, Herpes simplex, Herpesviruses, Inflammation, Monocytes, Platelets, Smooth muscle cell proliferation