Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction

Research output: Contribution to journalArticle

Authors

External Institution(s)

  • Duke University Medical Center
  • Duke University

Details

Original languageEnglish (US)
Pages (from-to)142-150
Number of pages9
JournalJournal of cardiovascular translational research
Volume13
Issue number2
StatusPublished - Apr 1 2020
Peer-reviewedYes

Abstract

We evaluated the heterogeneity of outcomes among heart failure patients with ventricular recovery. The BEST trial studied patients with left ventricular ejection fraction (LVEF) ≤ 35%. Serial LVEF assessment was performed at baseline, 3 months, and 12 months. Heart failure with better ejection fraction (HFbEF) was defined as an LVEF > 40% at any point. Of the patients who survived to 1 year, 399 (21.3%) had HFbEF. Among subjects with HFbEF, 173 (43.4%) had “extended” recovery, 161 (40.4%) had “late” recovery, and 65 (16.3%) patients had “transient” recovery. Subjects with HFbEF had an improved event-free survival from death or first HF hospitalization compared to subjects without recovery (HR 0.50, 95% CI, 0.39–0.64, p < 0.001). Compared to “transient” recovery, “late” and “extended” recovery were associated with an improved event-free survival from all-cause death and HF hospitalization (HR 0.55, 95% CI, 0.34–0.90, p = 0.016). Our study shows patients with HFbEF to be a heterogeneous population with differing prognoses.

    Research areas

  • Heart failure with better ejection fraction, Heart failure with reduced ejection fraction, Recovery

Citation formats

APA

Van Kirk, J., Fudim, M., Green, C. L., & Karra, R. (2020). Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction. Journal of cardiovascular translational research, 13(2), 142-150. https://doi.org/10.1007/s12265-019-09919-9

Harvard

Van Kirk, J, Fudim, M, Green, CL & Karra, R 2020, 'Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction', Journal of cardiovascular translational research, vol. 13, no. 2, pp. 142-150. https://doi.org/10.1007/s12265-019-09919-9