Immune cell trafficking, lymphatics and hypertension

Research output: Contribution to journalReview article

Details

Original languageEnglish (US)
Pages (from-to)1978-1988
Number of pages11
JournalBritish Journal of Pharmacology
Volume176
Issue number12
StatusPublished - Jun 2019
Peer-reviewedYes

Abstract

Activated immune cell infiltration into organs contributes to the development and maintenance of hypertension. Studies targeting specific immune cell populations or reducing their inflammatory signalling have demonstrated a reduction in BP. Lymphatic vessels play a key role in immune cell trafficking and in resolving inflammation, but little is known about their role in hypertension. Studies from our laboratory and others suggest that inflammation-associated or induction of lymphangiogenesis is organ protective and anti-hypertensive. This review provides the basis for hypertension as a disease of chronic inflammation in various tissues and highlights how renal lymphangiogenesis is a novel regulator of kidney health and BP. Linked Articles: This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.

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Balasubbramanian, D, Lopez Gelston, CA, Rutkowski, JM & Mitchell, BM 2019, 'Immune cell trafficking, lymphatics and hypertension', British Journal of Pharmacology, vol. 176, no. 12, pp. 1978-1988. https://doi.org/10.1111/bph.14370