Immune interventions in stroke

Research output: Contribution to journalReview article

Authors

External Institution(s)

  • Tianjin Medical University
  • Weill Cornell Medical College

Details

Original languageEnglish (US)
Pages (from-to)524-535
Number of pages12
JournalNature Reviews Neurology
Volume11
Issue number9
StatusPublished - Sep 7 2015
Peer-reviewedYes

Abstract

Approaches for the effective management of acute stroke are sparse, and many measures for brain protection fail. However, our ability to modulate the immune system and modify the progression of multiple sclerosis is increasing. As a result, immune interventions are currently being explored as therapeutic interventions in acute stroke. In this Review, we compare the immunological features of acute stroke with those of multiple sclerosis, identify unique immunological features of stroke, and consider the evidence for immune interventions. In patients with acute stroke, microglial activation and cell death products trigger an inflammatory cascade that damages vessels and the parenchyma within minutes to hours of the ischaemia or haemorrhage. Immune interventions that restrict brain inflammation, vascular permeability and tissue oedema must be administered rapidly to reduce acute immune-mediated destruction and to avoid subsequent immunosuppression. Preliminary results suggest that the use of drugs that modify disease in multiple sclerosis might accomplish these goals in ischaemic and haemorrhagic stroke. Further elucidation of the immune mechanisms involved in stroke is likely to lead to successful immune interventions.

Citation formats

APA

Fu, Y., Liu, Q., Anrather, J., & Shi, F. D. (2015). Immune interventions in stroke. Nature Reviews Neurology, 11(9), 524-535. https://doi.org/10.1038/nrneurol.2015.144

Harvard

Fu, Y, Liu, Q, Anrather, J & Shi, FD 2015, 'Immune interventions in stroke', Nature Reviews Neurology, vol. 11, no. 9, pp. 524-535. https://doi.org/10.1038/nrneurol.2015.144