Impact of Autologous Mesenchymal Stem Cell Infusion on Neuromyelitis Optica Spectrum Disorder: A Pilot, 2-Year Observational Study

Research output: Contribution to journalArticle

Authors

  • Ying Fu
  • Yaping Yan
  • Yuan Qi
  • Li Yang
  • Ting Li
  • Ningnannan Zhang
  • Chunshui Yu
  • Lei Su
  • Rui Zhang
  • Yi Shen
  • Song Lin
  • Qiang Liu
  • Zonghong Shao
  • Zhongchao Han
  • Fu Dong Shi

External Institution(s)

  • Tianjin Medical University
  • Chinese Academy of Medical Sciences

Details

Original languageEnglish (US)
Pages (from-to)677-685
Number of pages9
JournalCNS Neuroscience and Therapeutics
Volume22
Issue number8
StatusPublished - Aug 1 2016
Peer-reviewedYes

Abstract

Aims: We evaluate safety and efficacy of autologous bone marrow-derived mesenchymal stem cells (MSCs) as a potential treatment for neuromyelitis optica spectrum disorder (NMOSD). Methods: Fifteen patients with NMOSD were recruited. All patients received a single intravenous infusion of 1.0 × 108 autologous MSC within 3–4 generations derived from bone marrow. The primary endpoints of the study were efficacy as reflected by reduction in annualized relapse rates (ARRs) and inflammatory lesions observed by MRI. Results: At 12 months after MSC infusion, the mean ARR was reduced (1.1 vs. 0.3, P = 0.002), and the T2 or gadolinium-enhancing T1 lesions decreased in the optic nerve and spinal cord. Disability in these patients was reduced (EDSS, 4.3 vs. 4.9, P = 0.021; visual acuity, 0.4 vs. 0.5, P = 0.007). The patients had an increase in retinal nerve fiber layer thickness, optic nerve diameters and upper cervical cord area. We did not identify any serious MSC-related adverse events. At 24 months of MSC infusion, of 15 patients, 13 patients (87%) remained relapse-free, the mean ARR decreased to 0.1; the disability of 6 patients (40%) was improved, and the mean EDSS decreased to 4.0. Conclusions: This pilot trial demonstrates that MSC infusion is safe, reduces the relapse frequency, and mitigates neurological disability with neural structures in the optic nerve and spinal cord recover in patients with NMOSD. The beneficial effect of MSC infusion on NMOSD was maintained, at least to some degree, throughout a 2-year observational period.

    Research areas

  • Mesenchymal stem cells, Neuromyelitis optica spectrum disorder, Recovery, Relapse, Treatment

Citation formats

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Fu, Y, Yan, Y, Qi, Y, Yang, L, Li, T, Zhang, N, Yu, C, Su, L, Zhang, R, Shen, Y, Lin, S, Liu, Q, Shao, Z, Han, Z & Shi, FD 2016, 'Impact of Autologous Mesenchymal Stem Cell Infusion on Neuromyelitis Optica Spectrum Disorder: A Pilot, 2-Year Observational Study', CNS Neuroscience and Therapeutics, vol. 22, no. 8, pp. 677-685. https://doi.org/10.1111/cns.12559