Infection prevention using affinity polymer-coated, synthetic meshes in a pig hernia model

Research output: Contribution to journalArticle


External Institution(s)

  • Washington University St. Louis
  • Case Western Reserve University
  • Cleveland Clinic Foundation


Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalJournal of Surgical Research
StatusPublished - Nov 2017


Background Given concern for hernia mesh infection, surgeons often use biologic mesh which may provide reduced risk of infection but at the cost of decreased repair durability. We evaluated mesh coating to provide sustained release of antibiotics to prevent prosthetic mesh infection and also allow a durable repair. Materials and methods Cyclodextrin-based polymer was crosslinked onto multifilament polyester mesh and loaded with vancomycin (1.75 mg/cm2). Pigs received modified meshes (n = 6) or normal, untreated meshes (n = 4), which were implanted into acute 10 × 5 cm ventral hernia, then directly inoculated with 106 colony-forming unit (CFU) of methicillin-resistant Staphylococcus aureus (MRSA). These were compared to animals receiving normal, uninfected mesh. All mesh was secured in an underlay bridge manner, and after 30 d, the abdominal wall was removed for quantitative bacterial culture and biomechanical analysis. Results All animals survived 30 d. All six animals with coated mesh cleared MRSA infection. The four control animals did not clear MRSA (P = 0.005). Quantitative bacterial load was higher in standard mesh versus drug-delivery mesh group (2.34 × 104 versus 80.9 CFU/gm). These data were log10-transformed and analyzed by Welch's t-test (P = 0.001). Minimum number of CFUs detectable by assay (300) was used instead of zero. Biomechanical analysis of controls (1.82 N/mm infected; 1.71 N/mm uninfected) showed no difference to the modified meshes (1.31 N/mm) in tissue integration (P = 0.15). Conclusions We successfully prevented synthetic mesh infection in a pig model using a cyclodextrin-based polymer to locally deliver vancomycin to the hernia repair site and clearing antibiotic-resistant bacteria. Polymer coating did not impact the strength of the hernia repair.

    Research areas

  • Coating, Cyclodextrin, Hernia, Infection, Mesh, Pig, Polyester, Prevention, Synthetic, Treatment, Vancomycin

Citation formats


Blatnik, J. A., Thatiparti, T. R., Krpata, D. M., Zuckerman, S. T., Rosen, M. J., & von Recum, H. A. (2017). Infection prevention using affinity polymer-coated, synthetic meshes in a pig hernia model. Journal of Surgical Research, 219, 5-10.


Blatnik, JA, Thatiparti, TR, Krpata, DM, Zuckerman, ST, Rosen, MJ & von Recum, HA 2017, 'Infection prevention using affinity polymer-coated, synthetic meshes in a pig hernia model', Journal of Surgical Research, vol. 219, pp. 5-10.