Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

Research output: Contribution to journalArticle


  • Hee Sun Choi
  • Taejoon Won
  • Xuezhou Hou
  • Guobao Chen
  • William Bracamonte-Baran
  • Monica V. Talor
  • Ivana Jurčová
  • Ondrej Szárszoi
  • Lenka Čurnova
  • Ilja Stříž
  • Jody E. Hooper
  • Vojtěch Melenovský
  • Daniela Čiháková

External Institution(s)

  • Johns Hopkins University
  • Institute for Clinical and Experimental Medicine


Original languageEnglish (US)
Pages (from-to)2989-3003.e6
JournalCell reports
Issue number9
StatusPublished - Mar 3 2020


Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.

    Research areas

  • IL-33, Innate lymphoid cells, cardiac inflammation, eosinophils, group 2 innate lymphoid cells, mediastinum, pericarditis, serosal cavity

Citation formats


Choi, H. S., Won, T., Hou, X., Chen, G., Bracamonte-Baran, W., Talor, M. V., ... Čiháková, D. (2020). Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. Cell reports, 30(9), 2989-3003.e6.


Choi, HS, Won, T, Hou, X, Chen, G, Bracamonte-Baran, W, Talor, MV, Jurčová, I, Szárszoi, O, Čurnova, L, Stříž, I, Hooper, JE, Melenovský, V & Čiháková, D 2020, 'Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis', Cell reports, vol. 30, no. 9, pp. 2989-3003.e6.