Ion channel traffi cking and control of arterial contractility

Research output: Chapter in Book/Report/Conference proceedingChapter

Authors

External Institution(s)

  • University of Tennessee Health Science Center

Details

Original languageEnglish (US)
Title of host publicationVascular Ion Channels in Physiology and Disease
StatusPublished - Jan 1 2016

Abstract

Ion channels control many cellular processes, including neuronal excitability and arterial contractility. Vascular smooth muscle cell (myocyte) plasma membrane ion channels regulate membrane potential and extracellular calcium (Ca 2+) infl ux, which alters regional blood fl ow and systemic blood pressure. Ion channels can be homomers or heteromers of several pore-forming subunits and may associate with auxiliary subunits that can modify channel properties, including activity and surface expression. Recent studies have investigated pathways that control the surface expression of some plasma membrane ion channels in myocytes. These fi ndings have also found that vasoregulatory stimuli can control the number of plasma membrane ion channels to regulate contractility. Here, we review current literature describing mechanisms of traffi cking of voltage-gated K +(Kv), voltagegated Ca 2+(Cav1.2), large-conductance Ca 2+-activated potassium (BK Ca) and transient receptor potential (TRP) channels in arterial myocytes. These studies indicate that regulated ion channel traffi cking is a functional mechanism to control vascular contractility.

    Research areas

  • Accessory subunits, Ion channel, Protein trafficking

Citation formats

APA

Leo, M. D. M., & Jaggar, J. H. (2016). Ion channel traffi cking and control of arterial contractility. In Vascular Ion Channels in Physiology and Disease (pp. 153-168). Springer International Publishing. https://doi.org/10.1007/978-3-319-29635-7_7

Harvard

Leo, MDM & Jaggar, JH 2016, Ion channel traffi cking and control of arterial contractility. in Vascular Ion Channels in Physiology and Disease. Springer International Publishing, pp. 153-168. https://doi.org/10.1007/978-3-319-29635-7_7