Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Research output: Contribution to journalArticle


  • Bishuang Cai
  • Paola Dongiovanni
  • Kathleen E. Corey
  • Xiaobo Wang
  • Igor O. Shmarakov
  • Ze Zheng
  • Canan Kasikara
  • Viralkumar Davra
  • Marica Meroni
  • Raymond T. Chung
  • Carla V. Rothlin
  • Robert F. Schwabe
  • William S. Blaner
  • Raymond B. Birge
  • Luca Valenti
  • Ira Tabas

External Institution(s)

  • IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
  • Harvard University
  • Columbia University
  • Rutgers - The State University of New Jersey, Newark
  • Yale University
  • University of Milan


Original languageEnglish (US)
Pages (from-to)406-421.e7
JournalCell metabolism
Issue number2
StatusPublished - Feb 4 2020


Genome-wide association studies have indicated that MerTK is a risk factor for liver fibrosis in NASH with an unknown mechanism. Cai et al. discovered that MerTK signaling in liver macrophages, which is enhanced in NASH owing to suppression of its cleavage by ADAM17, promotes TGF-β1 production, HSC activation, and liver fibrosis in NASH.

    Research areas

  • ADAM17, MerTK, MerTK cleavage, NASH, TGFβ;, hepatic stellate cells, liver fibrosis, macrophage, nonalcoholic steatohepatitis, retinoic acid

Citation formats


Cai, B., Dongiovanni, P., Corey, K. E., Wang, X., Shmarakov, I. O., Zheng, Z., ... Tabas, I. (2020). Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. Cell metabolism, 31(2), 406-421.e7.


Cai, B, Dongiovanni, P, Corey, KE, Wang, X, Shmarakov, IO, Zheng, Z, Kasikara, C, Davra, V, Meroni, M, Chung, RT, Rothlin, CV, Schwabe, RF, Blaner, WS, Birge, RB, Valenti, L & Tabas, I 2020, 'Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis', Cell metabolism, vol. 31, no. 2, pp. 406-421.e7.