Mitochondrial inner membrane protein, Mic60/mitofilin in mammalian organ protection

Research output: Contribution to journalReview article

External Institution(s)

  • University of Texas Health Science Center at San Antonio
  • Xinxiang Medical College

Details

Original languageEnglish (US)
Pages (from-to)3383-3393
Number of pages11
JournalJournal of cellular physiology
Volume234
Issue number4
StatusPublished - Apr 2019
Peer-reviewedYes

Abstract

The identification of the mitochondrial contact site and cristae organizing system (MICOS) in the inner mitochondrial membrane shed light on the intricate components necessary for mitochondria to form their signature cristae in which many protein complexes including the electron transport chain are localized. Mic60/mitofilin has been described as the core component for the assembly and maintenance of MICOS, thus controlling cristae morphology, protein transport, mitochondrial DNA transcription, as well as connecting the inner and outer mitochondrial membranes. Although Mic60 homologs are present in many species, mammalian Mic60 is only recently gaining attention as a critical player in several organ systems and diseases with mitochondrial-defect origins. In this review, we summarize what is currently known about the ever-expanding role of Mic60 in mammals, and highlight some new studies pushing the field of mitochondrial cristae organization towards potentially new and exciting therapies targeting this protein.

    Research areas

  • MICOS, Mic60/Mitofilin, cristae morphology, mitochondria, organ diseases