Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation

Research output: Contribution to journalArticle

Authors

External Institution(s)

  • St. Joseph's Hospital and Medical Center
  • Tianjin Medical University
  • University of California at Los Angeles

Details

Original languageEnglish (US)
Pages (from-to)243-252
Number of pages10
JournalNature Neuroscience
Volume19
Issue number2
StatusPublished - Jan 27 2016
Peer-reviewedYes

Abstract

Recovery from organ-specific autoimmune diseases largely relies on the mobilization of endogenous repair mechanisms and local factors that control them. Natural killer (NK) cells are swiftly mobilized to organs targeted by autoimmunity and typically undergo numerical contraction when inflammation wanes. We report the unexpected finding that NK cells are retained in the brain subventricular zone (SVZ) during the chronic phase of multiple sclerosis in humans and its animal model in mice. These NK cells were found preferentially in close proximity to SVZ neural stem cells (NSCs) that produce interleukin-15 and sustain functionally competent NK cells. Moreover, NK cells limited the reparative capacity of NSCs following brain inflammation. These findings reveal that reciprocal interactions between NSCs and NK cells regulate neurorepair.