Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure

Research output: Contribution to journalReview article


  • Serena B. Gumusoglu
  • Akanksha S.S. Chilukuri
  • Donna A. Santillan
  • Mark K. Santillan
  • Hanna E. Stevens

External Institution(s)

  • University of Iowa


Original languageEnglish (US)
Pages (from-to)253-268
Number of pages16
JournalTrends in Neurosciences
Issue number4
StatusPublished - Apr 2020


Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to negative child health outcomes. Here, we review epidemiological and basic neuroscience work from the past several decades linking prenatal preeclampsia to altered neurodevelopment. This work demonstrates increased rates of neuropsychiatric disorders [e.g., increased autism spectrum disorder, attention deficit hyperactivity disorder (ADHD)] in children of preeclamptic pregnancies, as well as increased rates of cognitive impairments [e.g., decreased intelligence quotient (IQ), academic performance] and neurological disease (e.g., stroke and epilepsy). We also review findings from multiple animal models of preeclampsia. Manipulation of key clinical preeclampsia processes in these models (e.g., placental hypoxia, immune dysfunction, angiogenesis, oxidative stress) causes various disruptions in offspring, including ones in white matter/glia, glucocorticoid receptors, neuroimmune outcomes, cerebrovascular structure, and cognition/behavior. This animal work implicates potentially high-yield targets that may be leveraged in the future for clinical application.

    Research areas

  • animal models, neurodevelopment, preeclampsia, prenatal risk

Citation formats


Gumusoglu, S. B., Chilukuri, A. S. S., Santillan, D. A., Santillan, M. K., & Stevens, H. E. (2020). Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure. Trends in Neurosciences, 43(4), 253-268.


Gumusoglu, SB, Chilukuri, ASS, Santillan, DA, Santillan, MK & Stevens, HE 2020, 'Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure', Trends in Neurosciences, vol. 43, no. 4, pp. 253-268.