Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

Research output: Contribution to journalArticle

Authors

External Institution(s)

  • University of California at Davis
  • VA Medical Center
  • University of Duisburg-Essen
  • Maastricht University
  • University of California at Los Angeles
  • Victor Chang Cardiac Research Institute
  • Brown University
  • University of Debrecen
  • University of Utah
  • Washington University St. Louis

Details

Original languageEnglish (US)
Pages (from-to)2229-2252
Number of pages24
JournalJournal of Physiology
Volume595
Issue number7
StatusPublished - Apr 1 2017
Peer-reviewedYes

Abstract

Abstract: This is the second of the two White Papers from the fourth UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling and Arrhythmias (3–4 March 2016), a biennial event that brings together leading experts in different fields of cardiovascular research. The theme of the 2016 symposium was ‘K+ channels and regulation’, and the objectives of the conference were severalfold: (1) to identify current knowledge gaps; (2) to understand what may go wrong in the diseased heart and why; (3) to identify possible novel therapeutic targets; and (4) to further the development of systems biology approaches to decipher the molecular mechanisms and treatment of cardiac arrhythmias. The sessions of the Symposium focusing on the functional roles of the cardiac K+ channel in health and disease, as well as K+ channels as therapeutic targets, were contributed by Ye Chen-Izu, Gideon Koren, James Weiss, David Paterson, David Christini, Dobromir Dobrev, Jordi Heijman, Thomas O'Hara, Crystal Ripplinger, Zhilin Qu, Jamie Vandenberg, Colleen Clancy, Isabelle Deschenes, Leighton Izu, Tamas Banyasz, Andras Varro, Heike Wulff, Eleonora Grandi, Michael Sanguinetti, Donald Bers, Jeanne Nerbonne and Nipavan Chiamvimonvat as speakers and panel discussants. This article summarizes state-of-the-art knowledge and controversies on the functional roles of cardiac K+ channels in normal and diseased heart. We endeavour to integrate current knowledge at multiple scales, from the single cell to the whole organ levels, and from both experimental and computational studies.

    Research areas

  • K channel blockers, atrial fibrillation, cardiac K channels, cardiac arrhythmia, cardiac repolarization, computational modeling, hERG channel, long QT syndrome

Citation formats

APA

Chiamvimonvat, N., Chen-Izu, Y., Clancy, C. E., Deschenes, I., Dobrev, D., Heijman, J., ... Nerbonne, J. M. (2017). Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. Journal of Physiology, 595(7), 2229-2252. https://doi.org/10.1113/JP272883

Harvard

Chiamvimonvat, N, Chen-Izu, Y, Clancy, CE, Deschenes, I, Dobrev, D, Heijman, J, Izu, L, Qu, Z, Ripplinger, CM, Vandenberg, JI, Weiss, JN, Koren, G, Banyasz, T, Grandi, E, Sanguinetti, MC, Bers, DM & Nerbonne, JM 2017, 'Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics', Journal of Physiology, vol. 595, no. 7, pp. 2229-2252. https://doi.org/10.1113/JP272883