PPARγ and RhoBTB1 in hypertension

Research output: Contribution to journalReview article

Details

Original languageEnglish (US)
Pages (from-to)161-170
Number of pages10
JournalCurrent opinion in nephrology and hypertension
Volume29
Issue number2
StatusPublished - Mar 1 2020
Peer-reviewedYes

Abstract

Purpose of reviewThis review provides an up-to-date understanding of how peroxisome proliferator activated receptor γ (PPARγ) exerts its cardioprotective effect in the vasculature through its activation of novel PPARγ target genes in endothelium and vascular smooth muscle.Recent findingsIn vascular endothelial cells, PPARγ plays a protective role by increasing nitric oxide bioavailability and preventing oxidative stress. RBP7 is a PPARγ target gene enriched in vascular endothelial cells, which is likely to form a positive feedback loop with PPARγ. In vascular smooth muscle cells, PPARγ antagonizes the renin-angiotensin system, maintains vascular integrity, suppresses vasoconstriction, and promotes vasodilation through distinct pathways. Rho-related BTB domain containing protein 1 (RhoBTB1) is a novel PPARγ gene target in vascular smooth muscle cells that mediates the protective effect of PPARγ by serving as a substrate adaptor between the Cullin-3 RING ubiquitin ligase and phosphodiesterase 5, thus restraining its activity through ubiquitination and proteasomal degradation.SummaryIn the vasculature, PPARγ exerts its cardioprotective effect through its transcriptional activity in endothelium and vascular smooth muscle. From the understanding of PPARγ's transcription targets in those pathways, novel hypertension therapy target(s) will emerge.

    Research areas

  • Peroxisome proliferator activated receptor γ, Phosphodiesterase 5, Rho-related BTB domain containing protein 1, Vascular endothelial cells, Vascular smooth muscle cells

Citation formats

APA

Fang, S., & Sigmund, C. D. (2020). PPARγ and RhoBTB1 in hypertension. Current opinion in nephrology and hypertension, 29(2), 161-170. https://doi.org/10.1097/MNH.0000000000000579

Harvard

Fang, S & Sigmund, CD 2020, 'PPARγ and RhoBTB1 in hypertension', Current opinion in nephrology and hypertension, vol. 29, no. 2, pp. 161-170. https://doi.org/10.1097/MNH.0000000000000579