Reduced oxygen utilization in septic shock: disorder or adaptation?
Research output: Contribution to journal › Article
A fall in oxygen utilization during septic or endotoxic shock is thought to reflect circulatory hypoxia or mitochondrial dysfunction, but these pathology-oriented hypotheses do not explain all clinical observations. Here we discuss an alternative hypothesis of how oxygen utilization could fall as the result of a physiological thermometabolic adaptation.
- LPS, critical care oxygen, fever, hypothermia, hypoxia, metabolism, sepsis, temperature, thermogenesis