Reduced oxygen utilization in septic shock: disorder or adaptation?

Research output: Contribution to journalArticle

Details

Original languageEnglish (US)
Pages (from-to)447-448
Number of pages2
JournalTemperature
Volume2
Issue number4
StatusPublished - Oct 2 2015
Peer-reviewedYes

Abstract

A fall in oxygen utilization during septic or endotoxic shock is thought to reflect circulatory hypoxia or mitochondrial dysfunction, but these pathology-oriented hypotheses do not explain all clinical observations. Here we discuss an alternative hypothesis of how oxygen utilization could fall as the result of a physiological thermometabolic adaptation.

    Research areas

  • LPS, critical care oxygen, fever, hypothermia, hypoxia, metabolism, sepsis, temperature, thermogenesis