S -Nitrosothiols: Chemistry and reactions

Research output: Contribution to journalArticle


  • Caihong Zhang
  • Tyler D. Biggs
  • Nelmi O. Devarie-Baez
  • Shaomin Shuang
  • Chuan Dong
  • Ming Xian

External Institution(s)

  • Shanxi University
  • Washington State University Pullman
  • Washington State University Tri-Cities


Original languageEnglish (US)
Pages (from-to)11266-11277
Number of pages12
JournalChemical Communications
Issue number82
StatusPublished - Jan 1 2017


The formation of S-nitrosothiols (SNO) in protein cysteine residues is an important post-translational modification elicited by nitric oxide (NO). This process is involved in virtually every class of cell signaling and has attracted considerable attention in redox biology. On the other hand, their unique structural characters make SNO potentially useful synthons. In this review, we summarized the fundamental chemical/physical properties of SNO. We also highlighted the reported chemical reactions of SNO, including the reactions with phosphine reagents, sulfinic acids, various nucleophiles, SNO-mediated radical additions, and the reactions of acyl SNO species.

Citation formats


Zhang, C., Biggs, T. D., Devarie-Baez, N. O., Shuang, S., Dong, C., & Xian, M. (2017). S -Nitrosothiols: Chemistry and reactions. Chemical Communications, 53(82), 11266-11277. https://doi.org/10.1039/c7cc06574d


Zhang, C, Biggs, TD, Devarie-Baez, NO, Shuang, S, Dong, C & Xian, M 2017, 'S -Nitrosothiols: Chemistry and reactions', Chemical Communications, vol. 53, no. 82, pp. 11266-11277. https://doi.org/10.1039/c7cc06574d