Technical aspects of mouse intracranial aneurysm model
Research output: Chapter in Book/Report/Conference proceeding › Chapter
- University of California at San Francisco
- Tokushima University
Subarachnoid hemorrhage caused by the rupture of intracranial aneurysms results in catastrophic consequences with high morbidity and mortality. Mouse models of intracranial aneurysm help to improve our understanding of mechanisms for aneurysmal formation and rupture. Intracranial aneurysms can be induced by a combination of hypertension and a single injection of elastase into the cerebrospinal fluid in mice. In this model, subarachnoid hemorrhage due to aneurysmal rupture can be detected by a daily neurological examination. Our model will allow a better understanding of mechanisms of aneurysmal formation and rupture. Studies on the efficacy of pharmacological treatment on aneurysms are now conceivable to prevent aneurysmal rupture.
- Hypertension, Intracranial aneurysm, Mouse