Thalamic atrophy contributes to low slow wave sleep in neuromyelitis optica spectrum disorder

Research output: Contribution to journalArticle

Authors

  • Lei Su
  • Yujuan Han
  • Rong Xue
  • Kristofer Wood
  • Fu Dong Shi
  • Yaou Liu
  • Ying Fu

External Institution(s)

  • Tianjin Medical University
  • Tianjin Third Central Hospital
  • St. Joseph's Hospital and Medical Center
  • Vrije Universiteit Amsterdam
  • Capital Medical University

Details

Original languageEnglish (US)
Pages (from-to)691-696
Number of pages6
JournalAging and Disease
Volume7
Issue number6
StatusPublished - Jan 1 2016
Peer-reviewedYes

Abstract

Slow wave sleep abnormality has been reported in neuromyelitis optica spectrum disorder (NMOSD), but mechanism for such abnormality is unknown.To determine the structural defects in the brain that account for the decrease of slow wave sleep in NMOSD patients. Thirty-three NMOSD patients and 18 matched healthy controls (HC) were enrolled. Polysomnography was used to monitor slow wave sleep and three-dimensional T1-weighted MRIs were obtained to assess the alterations of grey matter volume. The percentage of deep slow wave sleep decreased in 93% NMOSD patients. Compared to HC, a reduction of grey matter volume was found in the bilateral thalamus of patients with a lower percentage of slow wave sleep (FWE corrected at cluster-level, p < 0.05, cluster size > 400 voxels). Furthermore, the right thalamic fraction was positively correlated with the decrease in the percentage of slow wave sleep in NMOSD patients (p < 0.05, FDR corrected, cluster size > 200 voxels). Our study identified that thalamic atrophy is associated with the decrease of slow wave sleep in NMOSD patients. Further studies should evaluate whether neurotransmitters or hormones which stem from thalamus are involved in the decrease of slow wave sleep.

    Research areas

  • Brain structure, Magnetic resonance imaging, Neuromyelitis optica spectrum disorder, Slow wave sleep

Citation formats

APA

Su, L., Han, Y., Xue, R., Wood, K., Shi, F. D., Liu, Y., & Fu, Y. (2016). Thalamic atrophy contributes to low slow wave sleep in neuromyelitis optica spectrum disorder. Aging and Disease, 7(6), 691-696. https://doi.org/10.14336/AD.2016.0419

Harvard

Su, L, Han, Y, Xue, R, Wood, K, Shi, FD, Liu, Y & Fu, Y 2016, 'Thalamic atrophy contributes to low slow wave sleep in neuromyelitis optica spectrum disorder', Aging and Disease, vol. 7, no. 6, pp. 691-696. https://doi.org/10.14336/AD.2016.0419