The relationship of cardiorespiratory function, fatigue and depressive symptoms in PLHIV

Research output: Contribution to journalArticle

Authors

  • Christine Horvat Davey
  • Joseph D. Perazzo
  • Marianne Vest
  • Richard A. Josephson
  • Vitor H.F. Oliveira
  • Abdus Sattar
  • Allison R. Webel

External Institution(s)

  • Case Western Reserve University
  • University of Cincinnati
  • Universidade Estadual de Londrina

Details

Original languageEnglish (US)
Pages (from-to)877-881
Number of pages5
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume32
Issue number7
StatusPublished - Jul 2 2020
Peer-reviewedYes

Abstract

Fatigue and depressive symptoms are prevalent and associated with poor clinical outcomes, though the underlying physiological mechanisms of fatigue and depression are poorly understood. We examined the impact of cardiorespiratory fitness (CRF) on fatigue and depressive symptoms in one-hundred and nine PLHIV. CRF was examined by maximal cardiorespiratory stress test and determined by peak oxygen uptake. Patient-reported fatigue was examined utilizing the HIV-Related Fatigue Scale. Depressive symptoms were examined with the Beck Depression Inventory and PROMISE 29. Data was collected at baseline and six months. Generalized estimating equations were used to determine the effect of CRF on fatigue and depressive symptoms over time. Participants were approximately 53 years old, 86% African American (n = 93), and 65% male (n = 70). After controlling for age and sex, fatigue was inversely associated with CRF (β = −0.163; p =.005). Depressive symptoms were not associated with CRF as measured by the BeckDepression Inventory (p =.587) nor PROMIS 29 (p =.290), but over time, depressive symptoms decreased (p =.051). Increased CRF was associated with decreased fatigue levels, but was not associated with depressive symptoms. These results should guide future research aimed at how CRF might inform interventions to improve fatigue in PLHIV.

    Research areas

  • Cardiorespiratory fitness, HIV, depressive symptoms, fatigue, symptom management

Citation formats

APA

Horvat Davey, C., Perazzo, J. D., Vest, M., Josephson, R. A., Oliveira, V. H. F., Sattar, A., & Webel, A. R. (2020). The relationship of cardiorespiratory function, fatigue and depressive symptoms in PLHIV. AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 32(7), 877-881. https://doi.org/10.1080/09540121.2019.1659920

Harvard

Horvat Davey, C, Perazzo, JD, Vest, M, Josephson, RA, Oliveira, VHF, Sattar, A & Webel, AR 2020, 'The relationship of cardiorespiratory function, fatigue and depressive symptoms in PLHIV', AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, vol. 32, no. 7, pp. 877-881. https://doi.org/10.1080/09540121.2019.1659920