The role of cofilin in age-related neuroinflammation

Research output: Contribution to journalReview article


External Institution(s)

  • University of Toledo


Original languageEnglish (US)
Pages (from-to)1451-1459
Number of pages9
JournalNeural Regeneration Research
Issue number8
StatusPublished - Jan 1 2020


Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active 'pro-inflammatory' state, causing chronic low-grade neuroinflammation. Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years, the underlying causes remain unclear. The identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and treatment. This will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the elderly. In this review, we have summarized the morphological and cellular changes in the aging brain, the effects of age-related neuroinflammation, and the potential role of cofilin-1 during neuroinflammation. We also discuss other factors contributing to brain aging and neuroinflammation.

    Research areas

  • aging, astrocyte-activation, cofilin, cofilin inhibitor, cofilin/actin rods, inflammaging, microglial activation, neurogenesis, neuroinflammation

Citation formats


Alsegiani, A. S., & Shah, Z. A. (2020). The role of cofilin in age-related neuroinflammation. Neural Regeneration Research, 15(8), 1451-1459.


Alsegiani, AS & Shah, ZA 2020, 'The role of cofilin in age-related neuroinflammation', Neural Regeneration Research, vol. 15, no. 8, pp. 1451-1459.