Voltage-gated sodium channels assemble and gate as dimers

Research output: Contribution to journalArticle

Authors

External Institution(s)

  • Case Western Reserve University
  • University of Illinois at Urbana-Champaign
  • Université de Nantes

Details

Original languageEnglish (US)
Article number2077
JournalNature communications
Volume8
Issue number1
StatusPublished - Dec 1 2017
Peer-reviewedYes

Abstract

Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.

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Clatot, J, Hoshi, M, Wan, X, Liu, H, Jain, A, Shinlapawittayatorn, K, Marionneau, C, Ficker, E, Ha, T & Deschênes, I 2017, 'Voltage-gated sodium channels assemble and gate as dimers', Nature communications, vol. 8, no. 1, 2077. https://doi.org/10.1038/s41467-017-02262-0