Voltage-gated sodium channels assemble and gate as dimers
Research output: Contribution to journal › Article
- Case Western Reserve University
- University of Illinois at Urbana-Champaign
- Université de Nantes
Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.